This paper reviewed the advances of the study on the long circulating nanoparticles in recent years from the dissection biological basis, dose form design theory and application prospects depending on the documents.

Anticancer effect of aclacinnomycin a long circulation microemulsions in small dosage chemotherapy

Study on the Preparation Procedure of Crebanine Nanoparticles;

Preparation of 5-fluorouracil PLGA nanoparticles;

PEGylated polycyanoacrylate nanoparticles as salvicine carriers: synthesis, preparation, and in vitro characterization;

Preparation of ketoprofen-polybutylcyanoacrylate-nanoparticles;

Studies on the Process of Liver-targeted Oxymatrine Nanoparticle;

The technology of preparation of poly (DLlactide) aclacinomycin nanoparticle;

Objectives: The biodegradable macromolecular poly(ethylene glycol)-poly (D,L-lac- tide) block copolymer (PEG-PLA) was synthesized by opening ring polymerization, then long-circulating nanoparticles containing sodium ozagrel (SOG-LCN), which can release in a long time, was prepared by modern nanoparticles preparation technique, in which PEG-PLA was used as carrier and SOG was used as model drug.

In thispaper,the history and developing tendency of magnetic carries of medicine are introduced,the methods of preparingmagnetic microspheres,magnetic liposomes,and magnetic nanoparticles are analysed and discussed.