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1)  High mobility group A1
高迁移率族蛋白A1
2)  HMGA1
高迁移率蛋白家族A1
1.
Objective:To investigate the inhibitory effects of high mobility group A1 (HMGA1) small interference RNA (siRNA) on the migration of ovary carcinoma cell lines in vitro.
目的:探讨高迁移率蛋白家族A1(high mobility group A1,HMGA1)基因小分子干扰RNA对卵巢癌转移抑制的机理。
3)  high mobility group protein A
高迁移率族蛋白A
1.
Objective: To investigate the expression and significance of high mobility group protein A1 (HMGA1)and high mobility group protein A2 (HMGA2)in endometrial carcinoma cell lines AN3CA, ECC-1, Ishikawa and tissue specimens of carcinomatous endometrium and normal endometrium.
目的:探讨高迁移率族蛋白A1(high mobility group protein A1, HMGA1)与高迁移率族蛋白A2(high mobility group protein A2, HMGA2)在子宫内膜癌细胞系AN3CA、ECC-1、Ishikawa以及子宫内膜癌组织、正常子宫内膜组织中的表达及意义。
2.
Objective:To detect the expression of high mobility group protein A (HMGA) in male mouse testicular cell lines TM4, GC-1spg and GC-2spd(ts), and to pave the theoretical ground for further investigation of the action mechanism of the HMGA gene in male mouse spermatogenesis.
目的:检测高迁移率族蛋白A(HMGA)在雄性小鼠生殖细胞株TM4、GC-1spg、GC-2spd(ts)中的表达,为深入探讨HMGA基因在小鼠精子发生过程中的作用机制奠定理论基础。
4)  High Mobility Group Box-1 Protein
高迁移率族蛋白B1
1.
Effects of NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) on mRNA expression of high mobility group box-1 protein in organs of rats with endotoxic shock;
NF-κB抑制剂对内毒素休克大鼠高迁移率族蛋白B1表达的影响
2.
Effect of lipopolysaccharide on stimulating high mobility group box-1 protein expression in peritoneal macrophages in rats and its potential signaling mechanism;
大鼠腹腔巨噬细胞高迁移率族蛋白B1诱生机制的初步探讨
3.
Study on high mobility group box-1 protein inducing endothelial cell activation in vitro;
高迁移率族蛋白B1对血管内皮细胞ECV-304活化作用的研究
5)  HMGB1
高迁移率族蛋白B1
1.
Preparation of HMGB1 Monoclonal Antibody and Its Application in Competitive ELISA;
高迁移率族蛋白B1单克隆抗体的制备及其在竞争ELISA中的应用
2.
Objective:To investigate the effect of shuxuening parenteral solution on the changes of HMGB1 and C response protein and lipid peroxidation in the blood of COPD patients.
目的:观察舒血宁注射液对COPD患者血液高迁移率族蛋白B1(high mobility group protein box-1,HMGB1)水平、血清脂质过氧化反应程度及C反应蛋白(Creactive protein,CRP)含量的影响。
3.
Objective To prepare monoclonal antibody specific for HMGB1 and establish a direct competitive ELISA for assaying serum HMGB1.
目的制备高迁移率族蛋白B1(HMGB1)单克隆抗体和建立HMGB1的直接竞争ELISA测定方法。
6)  HMGB1
高迁移率族蛋白1
1.
Expression and Clinical Significances of HMGB1 and EGFr vⅢ in Breast Cancer;
高迁移率族蛋白1及生长因子受体Ⅲ在乳腺癌组织中的表达及其临床意义
2.
Effect of HMGB1 on endothelial cells in sepsis
高迁移率族蛋白1在脓毒症血管内皮细胞激活过程中的作用
3.
Objective To detect the expression of HMGB1 in the serum and sputum of the patients with chronic cor pulmonale at high altitude area.
目的探讨高原慢性肺心病患者血液中高迁移率族蛋白1(high mobility group box1,HMGB1)变化及与痰液中相关因子的关系。
补充资料:高迁移率蛋白质
分子式:
CAS号:

性质:真核生物细胞核内的一组含量丰富的染色质非组蛋白。分子中含有25%碱性氨基酸和30%酸性氨基酸,分子量一般小于30 000。由于其在聚丙烯酰胺凝胶电泳中迁移率高而得名。从不同核酸酶选择性地水解有转录活性的染色质的实验中,发现HMG1和HMG2结合在链节DNA上,而HMG14和HMG17常与核小体核心部分的组蛋白八聚体和DNA结合。认为前者在链节处取代组蛋白亚基H1,后者则作用于核小体的核心颗粒,使之修饰成对DNase I等核酸酶更敏感的转录活性染色质,对基因表达起调控作用。荧光免疫法发现,细胞S期的HMG含量高于丝裂期。HMG14和HMG17还可用作亲和层析配体,分离有转录活性的染色质。

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