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1)  high mobility group box B1
高迁移率族蛋白B1基因
1.
Cloning of high mobility group box B1 gene and its relationship with development of neural tube;
高迁移率族蛋白B1基因的克隆及其与神经管发育的相关关系
2)  High Mobility Group Box-1 Protein
高迁移率族蛋白B1
1.
Effects of NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) on mRNA expression of high mobility group box-1 protein in organs of rats with endotoxic shock;
NF-κB抑制剂对内毒素休克大鼠高迁移率族蛋白B1表达的影响
2.
Effect of lipopolysaccharide on stimulating high mobility group box-1 protein expression in peritoneal macrophages in rats and its potential signaling mechanism;
大鼠腹腔巨噬细胞高迁移率族蛋白B1诱生机制的初步探讨
3.
Study on high mobility group box-1 protein inducing endothelial cell activation in vitro;
高迁移率族蛋白B1对血管内皮细胞ECV-304活化作用的研究
3)  HMGB1
高迁移率族蛋白B1
1.
Preparation of HMGB1 Monoclonal Antibody and Its Application in Competitive ELISA;
高迁移率族蛋白B1单克隆抗体的制备及其在竞争ELISA中的应用
2.
Objective:To investigate the effect of shuxuening parenteral solution on the changes of HMGB1 and C response protein and lipid peroxidation in the blood of COPD patients.
目的:观察舒血宁注射液对COPD患者血液高迁移率族蛋白B1(high mobility group protein box-1,HMGB1)水平、血清脂质过氧化反应程度及C反应蛋白(Creactive protein,CRP)含量的影响。
3.
Objective To prepare monoclonal antibody specific for HMGB1 and establish a direct competitive ELISA for assaying serum HMGB1.
目的制备高迁移率族蛋白B1(HMGB1)单克隆抗体和建立HMGB1的直接竞争ELISA测定方法。
4)  high mobility group box 1
高迁移率族蛋白B1
1.
Objective To investigate the influence of Ethyl pyruvate(EP) on the level of high mobility group box 1 (HMGB1) in brain injury of infant rats induced by lipopolysaccharide (LPS) and its significance.
目的探讨丙酮酸乙酯(EP)对脂多糖(LPS)致幼年大鼠脑损伤中高迁移率族蛋白B1(HMGB1)表达水平的影响及意义。
2.
Objective:To study the effects of Salvia miltiorrhiza on the release of high mobility group box 1(HMGB1) from endotoxin-stimulated macrophages and serum HMGB1 level of endotoxemia mice.
目的:研究丹参对内毒素脂多糖(lipopolysaccharide,LPS)激活后巨噬细胞高迁移率族蛋白B1(high mob-ility group box 1,HMGB1)释放和内毒素血症小鼠血清HMGB1水平的影响。
5)  high mobility group box 1 protein
高迁移率族蛋白B1
1.
Effects of Xuebijing injection(血必净注射液) on plasma high mobility group box 1 protein in rats after severe scald injury;
血必净注射液对烫伤大鼠高迁移率族蛋白B1的影响
2.
Changes in high mobility group box 1 protein levels after scald injury and its effect on splenic lymphocyte immunity in rats;
烫伤大鼠高迁移率族蛋白B1的变化及其对脾淋巴细胞免疫反应的影响
3.
Objective: High mobility group box 1 protein (HMGB1) as a late-acting cytokine mediates lethality of sepsis and systemic inflammation.
目的:高迁移率族蛋白B1(HMGB1)作为一种晚期炎症介质,介导了脓毒症和其他系统性炎症的致死性效应。
6)  high mobility group protein B1
高迁移率族蛋白B1
1.
Relation between level of expression of high mobility group protein B1 in hepatic tissue with the severity and prognosis of sepsis in rat;
高迁移率族蛋白B1表达水平与大鼠脓毒症严重程度及预后关系的实验研究
2.
Study of localization and translocation of human high mobility group protein B1 in eukaryotic cells;
人高迁移率族蛋白B1细胞内定位及移位研究
3.
Effects of staphylococcal enterotoxin B on high mobility group protein B1 in a guinea pig asthma model and its significance
金葡菌肠毒素B对哮喘豚鼠高迁移率族蛋白B1表达的影响及意义
补充资料:高迁移率蛋白质
分子式:
CAS号:

性质:真核生物细胞核内的一组含量丰富的染色质非组蛋白。分子中含有25%碱性氨基酸和30%酸性氨基酸,分子量一般小于30 000。由于其在聚丙烯酰胺凝胶电泳中迁移率高而得名。从不同核酸酶选择性地水解有转录活性的染色质的实验中,发现HMG1和HMG2结合在链节DNA上,而HMG14和HMG17常与核小体核心部分的组蛋白八聚体和DNA结合。认为前者在链节处取代组蛋白亚基H1,后者则作用于核小体的核心颗粒,使之修饰成对DNase I等核酸酶更敏感的转录活性染色质,对基因表达起调控作用。荧光免疫法发现,细胞S期的HMG含量高于丝裂期。HMG14和HMG17还可用作亲和层析配体,分离有转录活性的染色质。

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