The chronophamacokinetics of methotrexate;

Application Chronopharmacology in Drug Adiminiatering of Nursing;

Objective Discussing the relationship between human biological rhythm andchronopharmacology to guide the clinical delivery drugs which in order to improve the accurany ofusing drugs.

In the introduction of the topic mentioned above,this article strengthens the different grade of toxicities of anthracyclines resulted from its different usage The preliminary experience of 47 cases(73 chemotherapuetic cycles)who received doxorubicin of 96-hour infusion time schedule,circadian time schedule and their corresponding nursing care are discussed.

Guiding the Clinical Rational Use of Drugs Using Chronopharmacology;

Hour medical science from germination stage to formation stage and development period and maturity,the concept of hour medical science of TCM was first put forward by Chinese scholars from 20th century 70s.