1) haploidentical bone marrow transplantation
单倍体相合骨髓移植
1.
To explore the occurrence patterns of neurological complications following haploidentical bone marrow transplantation, a series of clinical data as the onset time, etiology, choices of therapies and prognosis in 10 patients with neurological disorders were summarized.
结果表明:74例接受单倍体相合骨髓移植病人中10例发生并发症,其中3例病人出现脑出血,感染3例(真菌感染,CMV脑炎,单纯疱疹病毒性脑炎各1例),癫痫、格林-巴利综合征、脑病和精神分裂症各1例,因神经系统并发症直接导致死亡的患者4例。
2.
To explore the occurrence patterns of pulmonary complications at different stages in haploidentical bone marrow transplantation, a series of clinical data as the onset time, etiology, management choices and prognosis in 18 patients with pulmonary disorders were summarized.
为了探讨单倍体相合骨髓移植术后不同时期肺部并发症发生情况 ,对 18例单倍体相合骨髓移植术后肺部并发症的发生时间、病因、治疗措施及预后等临床资料进行了总结分析。
3.
This study was purpused to analyze the characteristics of T cell receptor repertoire in target organs of murine graft-versus-host after haploidentical bone marrow transplantation(hiBMT) and the molecular characteristics of complementarity determining region3 (CDR3) repertoires of monoclonal T cell in liver, skin and ileum in murine after hiBMT.
本课题通过单倍体相合骨髓移植小鼠模型,研究GVHD靶器官的器官特异性T细胞受体谱型特点,以及GVHD靶器官克隆性T细胞的TCRBVCDR3分子特征。
2) haploidentical bone marrow transplantation
单倍相合骨髓移植
1.
This study was aimed to investigate the therapeutic effect of growth factor-primed donor peripheral mononuclear stem cell infusion (DMNCI) for patients with relapsed leukemia after haploidentical bone marrow transplantation (BMT).
本研究探讨同一供者外周血单个核细胞输注(DMNCI)治疗单倍相合骨髓移植后白血病复发的疗效和安全性。
2.
The purpose of study was to investigate the impact of killer immunoglobulin-like receptor (KIR) and its ligand on haploidentical bone marrow transplantation.
分析了74例KIR基因及其配体分子HLA-Cw的分布频率和特点,同时比较KIR分子配体缺失与否对单倍相合骨髓移植患者总体生存、无病生存、GVHD发生以及复发等的影响。
3) non-T cell depleted haploidentical BMT
单倍相合未去T细胞骨髓移植
4) Haploidentical bone marrow transplantation
单倍型骨髓移植
1.
Establishment of murine haploidentical bone marrow transplantation model and detection of T cell receptor clonal in target organs of graft-versus-host disease
单倍型骨髓移植小鼠移植物抗宿主病模型的建立及移植物抗宿主病靶器官T细胞受体克隆检测
5) haploidentical transplantation
单倍体相合移植
6) haploidentical hematopoietic stem cell transplantation
单倍体相合造血干细胞移植
1.
The aim of this study was to evaluate the impact of donor killer cell immunoglobulin-like receptor(KIR)and recipient HLA genotypes on outcome following haploidentical hematopoietic stem cell transplantation(HSCT).
本研究探讨供者杀伤细胞免疫球蛋白样受体(KIR)和受者人类白细胞抗原(HLA)基因型在单倍体相合造血干细胞移植(HSCT)预后中的意义。
2.
To investigate the characteristics and significance of reconstitution of peripheral blood plasmacytoid dendritic cell (PDC) precursors after allogeneic human leukocyte antigen mismatched/ haploidentical hematopoietic stem cell transplantation, and its relationship with chronic graft versus host disease(cGVHD)and relapse, 19 patients with leukemia were enrolled for this study.
为了探讨浆样树突状细胞(PDC)在单倍体相合造血干细胞移植术后重建的特点及其与慢性移植物抗宿主病(cGVHD)和患者复发的关系,采用流式细胞术对19例白血病患者移植后外周血树突状细胞(DC)亚群晚期重建进行动态监测,并将其与患者cGVHD和复发的关系进行分析。
补充资料：骨髓移植
| 骨髓移植 bone marrow transplantation 将正常骨髓由静脉输入患者体内，以取代病变骨髓的治疗方法。简称BMT。骨髓中有大量多能造血干细胞，具有自我复制和分化两种基本功能，在患者体内植活后，患者的造血功能和免疫功能即得以重建。 类型 根据骨髓的来源不同，BMT有3种类型：①同种异基因BMT。指人类不同个体间的移植，目前大多数BMT都指此而言，供者和受者的人类白细胞抗原(HLA）配型相合是移植成功的必要条件，亲兄弟姐妹间相合的机率是25％，无关供者相匹配的机率很少。②同基因BMT。即同卵双生子女间的BMT，效果最好。③自体BMT。即用自身的骨髓，不需供髓者，此法简便，易于推广，可广泛用于独生子女。 适应症 受者的年龄一般应小于45岁，自体BMA可高至55岁，应无重大内、外科疾病，具体适用于如下两类疾病，第一类是恶性疾病，包括：①完全缓解后的急性白血病，BMT后的5年生存率可达70％。②慢性粒细胞白血病的慢性期，80％可长期缓解或根治。③其他如难治性恶性淋巴瘤、多发性骨髓瘤、小细胞肺癌等常采用自体BMT，疗效显著。第二类是非恶性疾病如再生障碍性贫血和重症联合免疫缺陷病等。今后随着供髓者的选择、感染和移植物抗宿主病防治的解决，BMT必将被推广和显示巨大生命力。 |
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