Aim To establish a in vitro model for discovery and evaluation of uricosuric drug,we established a reliable rat isolated perfused kidney(IPK)preparation and observed urate excretion characterization in absence or presence of probenecid in perfusate by IPK.

Methods Thirty elderly male patients with primary hyperuricemia and underexcretion of uric acid were given benzbromarone 25mg/d for one week.

Objective:This study explored the assosiation between FEUA(fraction excretion of uric acid) and the coronary artery disease.

The urinary excretion kinetics of protoberberine alkaloids after oral administration of Xiexin decoction and different combinations of its constituent herbs in rats;