The urinary excretion kinetics of protoberberine alkaloids after oral administration of Xiexin decoction and different combinations of its constituent herbs in rats;

Aim To establish a in vitro model for discovery and evaluation of uricosuric drug,we established a reliable rat isolated perfused kidney(IPK)preparation and observed urate excretion characterization in absence or presence of probenecid in perfusate by IPK.