1) T-type calcium channel
T型钙通道
1.
Research progress of T-type calcium channels and the related drugs;
T型钙通道及其作用药物研究进展
2.
Objective:By observing the effect of mibefradil administered intrathecally on the mechanical and heat hyperalgesia following chronic constriction injury(CCI)of the sciatic nerve in rats,this study evaluates the role of T-type calcium channel in nociceptive transmission at the spinal level.
目的:观察脊髓水平T型钙通道阻滞剂米贝地尔(m ibefrad il)对坐骨神经慢性松结扎(CCI)大鼠机械和热痛阈的影响,探讨脊髓T型钙通道在伤害性信息传递中的作用。
3.
Objective:To study the relationship between the varicocele and the expression of human T-type calcium channel gene alphalH,alphal G in sperm and to provide a new direction for the pathophysiological mechanism of varicocele,in order to find new ideas for the diagnosis and treatment of infertility caused by varicocele.
目的:探讨精索静脉曲张(VC)患者精子细胞中人类T型钙通道α1H和α1G基因的表达与精索静脉曲张的关系,从而为精索静脉曲张病理生理机制的研究提供新的方向,为该症引起不育的基因诊断和治疗找到新的思路。
2) T type calcium channel
T型钙通道
1.
Aim To investigate the role of T type calcium channel of spinal cord and supraspinal on the pain threthold of the rats following chronic constriction injury(CCI) of the sciatic nerve.
目的观察鞘内和侧脑室内注射T型钙通道阻断剂对慢性坐骨神经结扎大鼠痛阈的影响,探讨脊髓和脊髓上水平T型钙通道在神经病理性疼痛中的作用。
2.
Objective:To compare the change of T type calcium channel activity between the detrusor overactivity (DO) and control rats, and explore its role in the pathogenesis of DO.
目的:研究T型钙通道在逼尿肌过度活动(detrusor overactivity,DO)大鼠模型中的改变并探索其在发病机制中的作用。
3) T-type calcium conductance
T-型钙离子通道
5) N-type calcium channel
N型钙通道
1.
Design and synthesis of spirocyclics blockers for N-type calcium channel and their biological activities
螺环类N型钙通道阻断剂的合成及其生物活性
2.
N-type calcium channels are mainly present at the presynaptic terminals of nociceptive neurons which are critical for pain transduction and modulation.
FDA已批准肽类阻断剂齐考诺肽鞘内给药,治疗全身性疼痛以及吗啡耐受或无效患者的严重慢性疼痛,证实N型钙通道是一个非常有意义的镇痛药物研究新靶标。
3.
Therefore, there are great progresses in the researches of novel analgesic agents targeted N-type calcium channel.
随着疼痛与N型钙离子通道之间关系的深入研究，人们发现，如果能研究出特异性、非阿片类、可口服、非肽类的N型钙通道阻断剂对解决慢性疼痛将是个突破。
6) L-type calcium channel
L-型钙通道
1.
Rapid atrial pacing downregulates mRNA expression of L-type calcium channel subunits and Kv4.3 potassium channel in rabbits;
快速心房起搏对家兔L-型钙通道和Kv4.3钾通道基因表达的影响
2.
Preparation and verification of antibody against L-type calcium channel subunits in rat ventricular myocytes;
抗大鼠心室肌细胞L-型钙通道亚单位抗体的制备与验证
3.
Effect of irbesartan on L-type calcium channel current in rabbit ventricular myocytes;
伊贝沙坦对兔心室肌细胞L-型钙通道电流的影响
补充资料：钙通道阻滞剂
钙通道阻滞剂
calcium channel blockers
又称“钙拮抗剂”、“慢通道阻滞剂”。指能选择性的阻滞细胞膜上的钙通道，减少Ca2+经钙通道内流的一类药物。主要有二氢吡啶类(如硝苯吡啶、尼莫地平）苯烷胺类(如维拉帕米）和硫氮■类(如硫氮■酮）等。在钙通道蛋白上有此三类药物的高亲和力结合位点。具有扩张血管、降低血压、减弱心肌收缩力和抑制血小板聚集等作用。主要用于治疗冠心病、高血压病、室上性心动过速、脑血管疾病等。不同药物对不同部位组织有相对选择性，如硝苯吡啶扩张冠状血管作用比较显著，而尼莫地平扩张脑血管作用较强。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条