Objective:To explore if there is any difference on aberrant methylationstatus of p16 gene between in the serum and in the tissue of colorectal cancer, andto study the association of the aberrant methylation status of p16 gene with someclinical factors, including tumor size, histologic types, degree of differentiation,Dukeχs stage, lymph node metastasis and family history.

Research of expression of p16 gene in K562/A02 cell line;

Antitumor efficacy of the adenoviral vector expressing p16 gene targeting the hepatocellular carcinoma models on nude mice;

The clinical significance of C-myc and P16 gene s expression in hepatocellular carcinoma;

Detection of methylation of p16 gene by nested methylation specific polymerase chain reaction;

Correlation of p16 hypermethylation with tumorigenesis and the development of gastric cancer;

Effects of exogenous p16 gene on the cell cycle and growth of renal carcinoma cell;

Analysis on point mutation of the CDKN2/p16 gene in lung cancer;

Study on the existence state of CDKN2/p16 gene in human primary malignant tumors;

Objective: To study the genetic alterations of pl6 gene in primary hepatocellular carcinoma.

Objective: To explore if there is any difference on aberrant methylation status of pl6 gene between in the serum and in the tissue of colorectal cancer, and to study the association of the aberrant methylation status of p16 gene with some clinical factors, including tumor size, histologic types, degree of differentiation, Duke s stage, lymph node metastasis and family history.