Quantitative determination of nalmefene-loaded poly(lactic-co-glycolic acid) microspheres by HPLC;

Preparation of Nalmefene Poly(lactic-co-glycolic acid) Microspheres;

Pharmacokinetics of nalmefene after a single or multiple intravenous doses in Chinese healthy volunteers;

Evaluation of the influencing factors on the ciliotoxicity of nalmefene hydrochloride nasal sprays;

HPLC determination of nalmefene hydrochloride and its related substances;

Pharmacokinetics of Nalmefene hydrochloride in healthy volunteers

OBJECTIVE To develop a rapid and sensitive HPLC-MS method for the analysis of namefene in human plasma,and study the pharmacokinetic characteristics of namefene hydrochloride injection after a single intravenous dose of 2 mg in healthy volunteers.

Fenner formula and modified Fenner formula have not been used widely because they could not calculate the radius of plastic area.

This paper describes the differences in expression form between Kaster formula and Fenner formula popularly used for plastic rock (soft rock), deviates their same points by taking stress circle as media and change tactics, expresses their same points in application by giving practical example in order to assist application of formulas in difficult construction project.

In consideration of different loading conditions during the construction and operation of a tunnel, different forms of the Fenner formula and the conditions for application for different plastic ranges are derived to determine the plastic ranges of axially symmetric circular tunnels in infinite homogeneous bodies.

Preparation of dextromethorphan oral sustained-release suspensions by ion exchange resin and the in-vitro release kinetics;

Determination of Dextromethorphan in Human Plasma by LC/MS and Study on Its Pharmacokinetics;

Effect of preoperative administration of Dextromethorphan on cough reflex during tracheal extubation;