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1)  aminoacyl-tRNA synthetase
氨基酰-tRNA合成酶
1.
Physiology,pathology and drug design related with editing of aminoacyl-tRNA synthetase;
氨基酰-tRNA合成酶编校相关的生理、病理效应和药物设计
2.
Recent studies show that aminoacyl-tRNA synthetases play important roles in cell life,such as taking part in intracellular RNA degrading,mRNA splicing,gene transcription regulation,immune response and angiogenesis.
氨基酰-tRNA合成酶(ARS)催化特异的氨基酸结合到对应tRNA上,确保mRNA高精度地翻译为蛋白质。
3.
Recent studies showed that some mitochondrial aminoacyl-tRNA synthetases are closely related with human diseases.
氨基酰-tRNA合成酶是一类古老的蛋白质,催化蛋白质生物合成中的第一步反应。
2)  aminoacyl tRNA synthetase
氨基酰tRNA合成酶
3)  bifunctinal aminoacyl-tRNA synthetase
双功能氨基酰-tRNA合成酶
4)  tyrosyl-tRNA synthetase
酪氨酰-tRNA合成酶
1.
Mutations in tyrosyl-tRNA synthetase, glycyl-tRNA synthetase and alanyl-tRNA synthetase from patients and mice models were identified to cause two subtypes of Charcot-Marie-Tooth disease and cerebellar Purkinje cell loss, respectively.
近期在对一些患有神经退行性疾病的病人和小鼠模型的研究中发现,位于酪氨酰-tRNA合成酶、甘氨酰-tRNA合成酶和丙氨酰-tRNA合成酶上的突变,可分别导致DI腓骨肌萎缩症(Charcot-Marie-Toothdisease,CMT)C型,腓骨肌萎缩症2D型及小脑浦肯雅(Purkinje)细胞丢失。
5)  glycyl-tRNA synthetase
甘氨酰-tRNA合成酶
1.
Mutations in tyrosyl-tRNA synthetase, glycyl-tRNA synthetase and alanyl-tRNA synthetase from patients and mice models were identified to cause two subtypes of Charcot-Marie-Tooth disease and cerebellar Purkinje cell loss, respectively.
近期在对一些患有神经退行性疾病的病人和小鼠模型的研究中发现,位于酪氨酰-tRNA合成酶、甘氨酰-tRNA合成酶和丙氨酰-tRNA合成酶上的突变,可分别导致DI腓骨肌萎缩症(Charcot-Marie-Toothdisease,CMT)C型,腓骨肌萎缩症2D型及小脑浦肯雅(Purkinje)细胞丢失。
6)  alanyl-tRNA synthetase
丙氨酰-tRNA合成酶
1.
Mutations in tyrosyl-tRNA synthetase, glycyl-tRNA synthetase and alanyl-tRNA synthetase from patients and mice models were identified to cause two subtypes of Charcot-Marie-Tooth disease and cerebellar Purkinje cell loss, respectively.
近期在对一些患有神经退行性疾病的病人和小鼠模型的研究中发现,位于酪氨酰-tRNA合成酶、甘氨酰-tRNA合成酶和丙氨酰-tRNA合成酶上的突变,可分别导致DI腓骨肌萎缩症(Charcot-Marie-Toothdisease,CMT)C型,腓骨肌萎缩症2D型及小脑浦肯雅(Purkinje)细胞丢失。
补充资料:氨基酰合成酶或氨基酰-tRNA合成酶


氨基酰合成酶或氨基酰-tRNA合成酶


  催化一个特定氨基酸与ATP形成AA-AMP,并使AA-AMP与特定的tRNA相结合形成AA-tRNA和游离AMP的酶,已发现20余种。
  
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