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1)  Hereditary nonpolyposis colorectal cancer
遗传性非息肉病性大肠癌
1.
Clinical characteristic,diagnosis and therapy of hereditary nonpolyposis colorectal cancer in 32 cases of 11 families;
遗传性非息肉病性大肠癌11个家系32例的临床特点与诊治
2.
Background and ObjectivesHereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal and dominantly inherited cancer predisposition caused by a constitutional defect in a mismatch repair (MMR) gene, with a disease penetrance that approaches 80-90%.
研究背景与目的 遗传性非息肉病性大肠癌(HNPCC)是由于DNA错配修复基因(MMR)发生胚系突变所致的一种单基因显性遗传性疾病,占所有结直肠癌的5%-15%,外显率达80%-90%,多见于青年患者(年龄≤40岁)。
2)  Hereditary non-polyposis colorectal cancer
遗传性非息肉病性大肠癌
1.
Hereditary non-polyposis colorectal cancer (HNPCC),also called Lynch syndrome,is an autosomal-dominantly inherited disease and is associated with germline mutations in mismatch repair(MMR)genes and microsatellite instability(MSI).
遗传性非息肉病性大肠癌(HNPCC)是一种由错配修复基因(MMR)突变造成的常染色体显性遗传病,又称Lynch综合征,是遗传性大肠癌的代表。
2.
Objective To investigate the relationship between microsatellite instability(MSI) and the expression of transforming growth factor β receptor II(TGFβRII),mismatch repaire(MMR) proteins in Hereditary Non-polyposis Colorectal Cancer(HNPCC).
目的观察遗传性非息肉病性大肠癌(HNPCC)和大肠腺瘤癌组织中TGFβRII、错配修复基因(hMLH1、hMSH2、hMSH6)蛋白表达和微卫星不稳定(MSI)的关系。
3)  hereditary non-polyposis colorectal cancer
遗传性非息肉性大肠癌
4)  herediary nonpolyposis colorectal cancer
遗传性非息肉病性大肠癌(HNPCC)
5)  hereditary nonpolyposis colorectal cancer(HNPCC)
遗传性非息肉病性大肠癌/HNPCC
6)  Hereditary nonpolyposis colorectal cancer
遗传性非息肉病性结直肠癌
1.
Hereditary nonpolyposis colorectal cancer:an analysis of 11 kindreds.;
遗传性非息肉病性结直肠癌11家系临床病理分析
2.
Clinical and pathological analysis of 8 hereditary nonpolyposis colorectal cancer pedigrees
遗传性非息肉病性结直肠癌8个家系临床及病理分析
3.
Objective To gain an insight into the large intragenic hMSH2 and hMLH1 deletions in Chinese hereditary nonpolyposis colorectal cancer(HNPCC)families.
目的了解中国人遗传性非息肉病性结直肠癌(HNPCC)家系hMSH2和hMLH1基因大片段缺失特点。
补充资料:非妊娠性绒癌


非妊娠性绒癌


非妊娠性绒癌在绒癌中占极少数。系来自自身一代原始生殖细胞分化异常所致(自体细胞变成)的肿瘤,故称为非妊娠性绒癌或原发性绒癌。男、女均可发病,在女性可发生于未婚或绝经后。原发瘤可发生于男、女性的生殖系统内,也可在生殖系统外(如纵隔、腹膜后、肺、食管、胃、肝、肾、膀胱、颅内等部位)。发生于生殖系统者,常和卵巢生殖细胞瘤(无性细胞瘤、未成熟型畸胎瘤、内胚窦瘤)或睾丸精原细胞瘤同时存在。由于本病罕见,多数的肿瘤组织和临床症状复杂,确诊困难。就诊病人也多为晚期,往往疗效差。化疗可以选用EMA/CO或PVB方案,合并卵巢精原细胞瘤或卵巢无性细胞瘤者,可加用放疗。
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