Constructions of Gcn5 shRNAs interfere the histone acetylation modification with stem cell differentiation;

Objective To construct 7 shRNA plasmids targeted to Gcn5 and to explore their role on histone acetylation in regulating MSCs differentiation into cardiomyocytes.

As acetylation of proteins facilitates the expression of proapoptotic genes and induces the degradation of oncoproteins and antiapoptotic proteins, HDACi induce apoptosis by activating the apoptotic signal transduction pathways at transcription and posttranslation levels.

Synthesis and pegylation of human parathyroid hormones (1-34);

The covalent attachment of PEG (pegylation) to peptides and proteins can significantly improve their pharmacological and biological properties, such as shielding immunogenic epitopes, preventing degradation by proteolytic enzymes, increasing solubility, reducing renal filtration and altering biodistribution.

Chemical modification the surface of lacquer film with titanium tetrachloride;

Study on pepsin′s chemical modification of nattokinase;

Polarize studies and chemical modifications of congo red compounds;