Determination of chiral impurity in S-Zopiclone by HPLC;

Methodology study of the content determination of chiral impurity in the S-zopiclone;

The chemical name of eszopiclone is (+)-(5S)-6-(5-chloropyridin-2-yl)-7-oxo- 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate.

Objective:This randomized,double-blind,zopiclone-controlled,multi-center clinical trial assessed the efficacy and safety of eszopiclone in treating patients with primary insomnia.

Study on the effect of zopiclone and eszopiclone in the treatment of insomniac patients by polysomnogram

Randomized controlled clinical trial on(+) zopiclone versus zopiclone in the treatment of insomnia;