1) Platelet-derived growth factor-BB
血小板衍生生长因子-BB
1.
MethodsHepatic stellate cells (HSCs) isolated from rats were primarily cultured in uncoated plastic culture dish for 7 days, then were incubated with 10~ -6 mmol/L SA-B and stimulated with 10 ng/ml transforming growth factor-β_1 (TGF-β_1) or platelet-derived growth factor-BB (PDGF-BB).
方法分离大鼠肝星状细胞(HSC),于无包被塑料培养皿中原代培养7天,继以10-6mmol/L SA-B孵育,再加10ng/ml的转化生长因子β1(TGF-β1)或血小板衍生生长因子-BB(PDGF-BB)刺激。
2) PDGF-BB
血小板衍生生长因子-BB
1.
Objectives:To investigate the inhibitory effect of Danshengsu on proliferation、collagen typeⅠsynthesis and Phosphorylated extracellular signal- regulated kinase 1/2 (P-ERK1/2)expression of rat hepatic stellate cell ( HSC ) stimulated by platelet derived growth factor-BB (PDGF-BB),and to elucidate the molecular mechanism of Danshensu against hepatic fibrosis.
目的观察丹参素对血小板衍生生长因子-BB (platelet derived growth factor-BB PDGF-BB)刺激大鼠肝星状细胞(hepatic stellate cell HSC )增殖、Ⅰ型胶原合成、磷酸化细胞外信号调节激酶1/2(Phosphorylated extracellular signal- regulated kinase 1/2 ,P-ERK1/2)表达的影响,探讨丹参素抗肝纤维化的分子机制。
2.
Real-time fluorescence quantitative PCR method was used to determine the effects of Qingfei oral liquid medicated serumon on the expression of TGF-β_1 and PDGF-BB mRNA genes.
观察清肺口服液含药血清对RSV感染后人胚肺成纤维细胞转化生长因子-β_1和血小板衍生生长因子-BB mRNA基因表达的影响。
3) platelet derived growth factor-BB
血小板衍生生长因子-BB
1.
Objective To explore the effects of platelet derived growth factor-BB(PDGF-BB)and basic fibroblast growth factor(bFGF)on alkaline phosphatase(ALP)activity in human periodontal ligament cells(hPDLCs)in vitro.
目的探讨血小板衍生生长因子-BB(PDGF-BB)和碱性成纤维细胞生长因子(bFGF)对人牙周膜(PDL)细胞碱性磷酸酶(ALPase)活性的影响。
4) platelet-derived growth factor BB
血小板衍生生长因子BB
1.
Objective:To explore the relationship among vascular endothelial growth factor C(VEGF-C),platelet-derived growth factor BB(PDGF-BB),lymphangiogenesis and lymph node metastasis in human non-small cell lung cancer(NSCLC).
目的:探讨血管内皮生长因子C(VEGF-C)和血小板衍生生长因子BB(PDGF-BB)在非小细胞肺癌(NSCLC)中的表达与淋巴管生成和淋巴结转移的关系。
2.
Objective To investigate the intracellular calcium concentration alteration induced by platelet-derived growth factor BB(PDGF-BB) and the mechanism of ion flux in cultured glomerular mesangial cells.
目的 研究血小板衍生生长因子BB(PDGF-BB)引起的肾小球系膜细胞内游离钙浓度变化及其离子流动机制。
5) platelet derived growth factor BB
血小板衍生生长因子BB
1.
Objective To investigate the relationship between the expression of platelet derived growth factor BB(PDGF-BB)、vascular endothelial growth factor C(VEGF-C)and the clinicopathologic parameters in colonic carcinoma,and to explore the difference of VEGF-C and PDGF-BB expression in primary tumor and metastatic lymph node.
目的探讨结肠癌组织中血小板衍生生长因子BB(PDGF-BB)、血管内皮生长因子C(VEGF-C)的表达,及其与肿瘤临床病理参数之间的关系;分析在结肠原发癌与相应淋巴结转移癌中VEGF-C、PDGF-BB表达是否存在差异。
2.
Significance of platelet derived growth factor BB on the development of cerebral vasospasm;
目的 探讨血小板衍生生长因子BB(PDGF BB)在蛛网膜下腔出血 (SAH)后的表达及其对正常脑血管的影响 。
6) PDGF-BB
血小板衍化生长因子-BB
1.
Objective To study the effect of interferon on TGFβ_1,MMP-1,PDGF-BB and ppGalNAc-T_2 in fibroblast of pathological scars and the mechanism of interferon on pathological scars.
目的在体外研究干扰素2b(INF-α2b)对瘢痕组织成纤维细胞转化生长因子-β1(TGF-β1)、基质金属蛋白酶-1(MMP-1)、血小板衍化生长因子-BB(PDGF-BB)以及糖基转移酶(ppGalNAc-T2)基因表达的作用,以求阐明干扰素对增生性瘢痕的作用机理。
补充资料：血小板衍生生长因子
分子式：
CAS号：
性质：platelet derired growth factor；PDGF 贮存于血小板α颗粒中的一种碱性蛋白质，是一些细胞，如纤维母细胞、平滑肌细胞、神经胶质细胞的促细胞分裂剂。包括PDGF-I和PDGF-II，二者所含蛋白质相同，仅糖苷含量各异，它们是由两个不同的多肽链由二硫键结合而成的二聚体，其中A链较大(PDGF-I中的A链为17 000，PDGF-II中的A链为15 000)，B链较小(14 000)。由血小板纯化得到的PDGF为AB、BB双聚体，许多肿瘤细胞中的PDGF为AA双聚体。目前认为PDGF在伤口愈合、胆固醇与磷酯合成的调节、动脉粥样硬化等多种生理及病理过程中起重要作用。
CAS号：
性质：platelet derired growth factor；PDGF 贮存于血小板α颗粒中的一种碱性蛋白质，是一些细胞，如纤维母细胞、平滑肌细胞、神经胶质细胞的促细胞分裂剂。包括PDGF-I和PDGF-II，二者所含蛋白质相同，仅糖苷含量各异，它们是由两个不同的多肽链由二硫键结合而成的二聚体，其中A链较大(PDGF-I中的A链为17 000，PDGF-II中的A链为15 000)，B链较小(14 000)。由血小板纯化得到的PDGF为AB、BB双聚体，许多肿瘤细胞中的PDGF为AA双聚体。目前认为PDGF在伤口愈合、胆固醇与磷酯合成的调节、动脉粥样硬化等多种生理及病理过程中起重要作用。
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