1) DNA methyltransferases 3A
DNA甲基转移酶3A
1.
Objective To investigate the function of DNA methyltransferases 3A(DNMT3A)in a series of biological process and carcinogenesis and to construct an eukaryotic siRNA targeting on DNMT3A to suppress the expression of DNMT3A gene.
目的:构建DNA甲基转移酶3A(DNA methyltransferases 3A,DNMT3A)siRNA重组质粒稳定表达载体,为进一步探讨DNMT3A在多种生物学过程及肿瘤发生发展中的机制提供工具。
2) DNA methyltransferase
DNA甲基转移酶
1.
Effects of preimplantation embryos on expressions of DNA methyltransferase 1 in mouse oviduct epithelial cells;
小鼠植入前胚胎对输卵管上皮细胞DNA甲基转移酶1表达的影响(英文)
2.
Effects of mouse preimplantation embryo on expression of DNA methyltransferase-1 mRNA in mouse oviductal epithelium.;
小鼠植入前胚胎对输卵管上皮细胞DNA甲基转移酶-1 mRNA的降调节作用
3.
Expression of mRNA for DNA methyltransferase 1, 3a and 3b in bladder carcinoma;
膀胱癌DNA甲基转移酶1、3a、3b基因的表达
3) DNA methyltransferase 1
DNA甲基转移酶1
1.
Expression of DNA methyltransferase 1 in human gastric cancer tissue and its significance;
DNA甲基转移酶1在胃癌组织中的表达及意义
2.
Expression of DNA methyltransferase 1 in human cervical carcinoma tissue and cells and its significance;
DNA甲基转移酶1在子宫颈癌组织和细胞中的表达及意义
3.
Expression of DNA methyltransferase 1 in transitional cell carcinoma of bladder
DNA甲基转移酶1蛋白在膀胱移行细胞癌中的表达及其临床意义
4) DNA methyltransferase
DNA甲基化转移酶
1.
Objective:To study transcription level and catalytic activity of DNA methyltransferase (Dnmts) in lung cancer cell line A549 exposed in 5-Aza-CdR (5-Aza-2’-deoxycitydine),and the role of Dnmts in the process.
目的:研究5-氮杂-2’-脱氧胞苷(5-Aza-2’-deoxycitydine,5-Aza-CdR)处理肺癌细胞株A549后,DNA甲基化转移酶(DNA methyltransferase,Dnmts)转录水平及其活性的变化,以及细胞生长状态的改变。
5) DNA methyltransferases
DNA甲基转移酶
1.
DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription,induce gene silencing at the participation of many regulators.
DNA甲基化由DNA甲基转移酶催化,在多种调节因子的参与下,与组蛋白修饰相互作用,抑制基因转录,导致基因沉默。
2.
It may result from down-regulating DNA methyltransferases, DNMT1 and DNMT3B, or up-regulating the histone acetylation that allows chromatin unfolding and the accessibility of regulators for transcriptional activation in the p15 promoter.
应用甲基化特异性聚合酶链反应(MSP)检测PHI作用前后Molt-4细胞株p15基因甲基化状态的变化;半定量逆转录-聚合酶链反应(RT-PCR)检测Molt-4细胞经过PHI处理后DNA甲基转移酶DNMT1、DNMT3A、DNMT3B、p15基因的mRNA的表达变化;用蛋白免疫印迹(Western blotting)检测Molt-4细胞经过PHI处理后的P15蛋白的表达。
3.
Objective To investigate the relationship between the expression of DNA methyltransferases(DNMT)and clinical prognosis in children with acute leukemia(AL).
目的通过检测DNA甲基转移酶(DNMT)基因在AL患儿中的表达水平,探讨其与临床预后之间的相关性。
6) DNA methyltransferase 3B
DNA甲基转移酶3B
1.
Objective To investigate the expression of DNA methyltransferase 3b (DNMT3b) and signal transducer and activator of transcription 3(STAT3) and their possible relationship.
目的探讨DNA甲基转移酶3b(DNMT3b)、信号转导子与转录激活子3(STAT3)在肝细胞肝癌(HCC)中的表达及其意义。
补充资料：转移
转移
metastasis
恶性肿瘤细胞(有时还指侵入的病原体）通过血管、淋巴管或其他途径，从原发病灶扩散到与其不直接相连的部位或器官，并在扩散区形成了同样的病变，如结核菌的转移，恶性肿瘤的转移。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条