1) DNA repair
DNA修复
1.
Advances in the research of DNA repair and cervical cancer;
DNA修复与宫颈癌的研究新进展
2.
Polymorphisms of DNA repair genes are predictive factors for the tumor response and prognosis to platinum chemotherapy;
DNA修复基因单核苷酸多态性预测铂类药物敏感性和预后
3.
Relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury;
DNA修复基因XRCC1多态性与辐射损伤易感性的关系
2) DNA repair enzyme
DNA修复酶
1.
hMSH2 deficiency of DNA repair enzyme and cell genetic stability;
DNA修复酶hMSH2缺陷与细胞遗传不稳定性
2.
Structures and functions of DNA repair enzymes;
DNA修复酶的结构和功能
3) DNA injury and DNA repair
DNA损伤与DNA修复
4) DNA repair
DNA损伤修复
1.
To date, at least 12 FA genes have been found deleted or mutated in FA cells, and 10 FA gene products form a core complex involved in FA/BRCA2 DNA repair pathway?FA pathway.
目前已经发现至少12种FA基因的缺失或突变能够引起FA表型的出现,其中10种相应的编码蛋白形成FA复合物共同参与FA/BRCA2 DNA损伤修复途径—FA途径。
2.
Previous studies show that p33 ING1b is involved in growth inhibition, apoptosis, chromatin remodeling, DNA repair, tumor suppression and cellular senescence, but its biochemical function and involvement in cellular senescence is still not fully uncharacterized.
p33ING1b是一个较晚发现的肿瘤抑制基因ING1的主要表达形式,但是它在细胞衰老过程中的作用特别是对衰老细胞DNA损伤修复的影响还没有被阐明。
3.
Objective:To establish and characterize mouse medulloblastoma(MB) cell lines with PARP-1 mutation,in order to explore the molecular machanism of MB,and to investigate the impact of PARP-1 on DNA repair proteins including Brca1、Nbs1、Ku70、Ku80 and RAD51 in the MB cells.
目的:利用PARP-1和p53基因双缺失的小鼠髓母细胞瘤细胞系,探讨DNA损伤修复因子Brca1、Nbs1、Ku70、Ku80和Rad51对小鼠髓母细胞瘤发生的意义及其相互作用关系。
5) DNA mismatch repair
DNA错配修复
1.
Methylation of DNA mismatch repair gene MLH1 and MSH2 in acquired multidrug-resistance of human small cell lung cells H446;
DNA错配修复基因甲基化在H446细胞获得性耐药中的作用
2.
Advances of researches on the composition and function of DNA mismatch repair system;
DNA错配修复系统组成和功能的研究进展
3.
Frequent Ki-ras Mutation in MSI-H Colorectal Cancer Deficient in DNA Mismatch Repair Genes;
DNA错配修复基因缺陷的MSI-H大肠癌频发Ki-ras基因点突变
6) DNA repair capacity
DNA修复能力
1.
Objective To explore the correlation between genetic polymorphisms of XRCC1,XPD,XRCC3and DNA repair capacity induced by benzene.
方法以确诊并已脱离苯作业的80名慢性苯中毒患者作为病例组,以同期接苯的62名苯作业工人为对照组,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析技术,检测XRCC1 C26304T(Arg194Trp)、G27466A(Arg280His)、G28152A(Arg399Gln)、G36189A(Gln632Gln)和XPD C22541A(Arg156Arg)、C23591T(Asp312Asn)、A35931C(Lys751Gln)以及XRCC3 C18067T(Thr241Met)位点的多态性,采用细胞阻滞微核试验和碱性彗星试验分别从细胞水平和分子水平检测DNA修复能力。
2.
[Objective] To detect the DNA repair capacity of cancer patients after the exposure to radiomimetic compounds.
方法采集20名不同类型肿瘤病人和20名非肿瘤病人的淋巴细胞,用浓度为20μg/ml的博来霉素(Bleomycin)作用30 min后,再经15 min修复,采用彗星试验检测Bleomycin暴露前后DNA损伤程度来评价DNA修复能力。
3.
OBJECTIVE To approach The Correlation of DNA repair capacity and cisplatin resistance in Advanced Non-Small-Cell Lung Cancer, and to provide theoretical supports for predicting the efficacy of cisplatin-based chemotherapy on Non-small-cell lung cancer patients.
目的：探讨晚期非小细胞肺癌患者(NSCLC)机体DNA修复能力(DNA repair capacity，DRC)与顺铂为基础方案化疗后产生耐药之间的关系，为临床预测晚期非小细胞肺癌患者对顺铂方案化疗是否有效提供理论依据。
补充资料：DNA修复
分子式：
CAS号：
性质：可以降低DNA碱基序列因遭受辐射和其他诱变因子所致损伤的一种机制。此过程是一种特异酶[包括DNA聚合酶(DNA连接酶)]催化反应。DNA修复系统保证了遗传有效突变率大大低于始发突变率。DNA修复是一由多种不同机制参与的复杂过程。有些在光照时增强，有些则需在无光条件下进行。
CAS号：
性质：可以降低DNA碱基序列因遭受辐射和其他诱变因子所致损伤的一种机制。此过程是一种特异酶[包括DNA聚合酶(DNA连接酶)]催化反应。DNA修复系统保证了遗传有效突变率大大低于始发突变率。DNA修复是一由多种不同机制参与的复杂过程。有些在光照时增强，有些则需在无光条件下进行。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条