1) diltiazem
地尔硫
1.
Compound 2 was then treated with thionyl chloride to give (4S,5R)-4-(4-methoxyphenyl)-5-ethoxycarbonyl-1,3-dioxathiolane 2-oxide in 85% yield, the latter compound is a key chiral intermediate for preparation of diltiazem .
以1,4-双(9-O-奎宁基)-2,3-二氮杂萘为手性配体,经锇催化的不对称二羟化反应将反式-对甲氧基肉桂酸乙酯转化为(2R,3S)-2,3-二羟基-3-(4-甲氧基苯基)丙酸乙酯(2),收率87%,ee值大于99%;2与氯化亚砜反应得到地尔硫的手性中间体(4S,5R)-4-(4-甲氧基苯基)-5-乙氧羰基-1,3-二氧杂-2-氧代硫杂环戊烷,收率85%。
2.
Objective To establish reversed phase HPLC method for simultaneous determination of the concentration of carbamazepine(CBZ)and diltiazem(DZ) in serum,using diazepam as internal standard.
目的建立反相高效液相色谱(HPLC)法,以安定为内标,同时测定血清中卡马西平(CBZ)和地尔硫(DZ)的浓度。
3.
The delayed-release tablets were prepared by film-coating technology using diltiazem hydrochloride asmodel drug, insoluble ethylcellulose as retarding material and Eudragit L100 and S100 as porous agents.
以盐酸地尔硫为模型药物,不溶性乙基纤维素为阻滞材料,Eudragit L100及S100为致孔剂,采用薄膜包衣法制得延迟释放片。
2) diltiazem
地尔硫卓
1.
Effect of Diltiazem on the expression of proto-oncogene in proliferated vascular smooth muscle cells;
地尔硫卓对增殖血管平滑肌细胞的原癌基因表达的影响
2.
A Comparative Study on the Efficacy and Safety of Intravenous Diltiazem and Metoprolol in Elderly Heart Failure Patients with Rapid Atrial Fibrillation;
静脉应用地尔硫卓和美托洛尔治疗老年心功能衰竭伴心房颤动快速心室率的疗效和安全性比较
3.
Curative effect and safety of diltiazem in treatment of patients with unstable angina;
口服地尔硫卓治疗不稳定型心绞痛的疗效和安全性
3) diltiazem
地尔硫
1.
Effect of benazepril and diltiazem on endothelium function in patients with cardiac syndrome X;
贝那普利、地尔硫对心脏X综合征患者内皮功能的影响
2.
Effects of Diltiazem on Intracellular Mitochondria Membrance Potential of Human Vascular Endothelial Cells under Hypoxia;
地尔硫对缺氧所致血管内皮细胞线粒体膜电位变化的保护作用
3.
Effect of MARCKS-related peptide and Diltiazem on Mucin 5AC secretion in a rat model of airway mucus hypersecretion;
MARCKS相关多肽与地尔硫对大鼠气道黏液高分泌模型MUC5AC分泌的影响
4) diltiazem
地尔硫唑
1.
Effects of diltiazem on down-regulation of lymphocyte B-adrenoceptors in patients with chronic congestive heart failure;
地尔硫唑对慢性充血性心力衰竭患者淋巴细胞膜β肾上腺素受体下调的影响(英文)
5) Diltiazem
地尔硫革
1.
Influences of M etoprolol, Verapamil, and Diltiazem on Hemodynamics During Tracheal Extubation;
目的:观察气管拔管时美托洛尔、维拉帕米和地尔硫革对血流动力学的影响。
6) Pretiadil
普硫地尔
补充资料：地尔硫
分子式：C22H26N2O4S·HCl
分子量：450.98
CAS号：33286-22-5
性质：白色结晶或结晶性粉末。熔点187-188℃。易溶于水、甲醇、氯仿，难溶于无水乙醇，不溶于苯。无臭，味苦。
制备方法：由2-氨基硫酚与对甲氧苯基环氧丙酸乙酯缩合得2-（4-甲氧基苯基）-3-羟基-1，5-苯并硫氮杂 -4（5H）-酮。再经酰化、与二甲氨基氯乙烷缩合、成盐制得硫氮卓酮。
用途：钙通道阻滞药，用于室上性心律失常、心绞痛、老年人高血压等。本品为冠脉扩张药，对心绞痛有效。用于运动性绞痛及陈旧性心肌梗塞引起的心绞痛治疗。本品对雌小鼠口服LD50为640毫克/公斤，雄大鼠口服LD50为560毫克/公斤。
分子量：450.98
CAS号：33286-22-5
性质：白色结晶或结晶性粉末。熔点187-188℃。易溶于水、甲醇、氯仿，难溶于无水乙醇，不溶于苯。无臭，味苦。
制备方法：由2-氨基硫酚与对甲氧苯基环氧丙酸乙酯缩合得2-（4-甲氧基苯基）-3-羟基-1，5-苯并硫氮杂 -4（5H）-酮。再经酰化、与二甲氨基氯乙烷缩合、成盐制得硫氮卓酮。
用途：钙通道阻滞药，用于室上性心律失常、心绞痛、老年人高血压等。本品为冠脉扩张药，对心绞痛有效。用于运动性绞痛及陈旧性心肌梗塞引起的心绞痛治疗。本品对雌小鼠口服LD50为640毫克/公斤，雄大鼠口服LD50为560毫克/公斤。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条