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1)  Diltiazem hydrochloride
盐酸地尔硫卓
1.
Preparation of diltiazem hydrochloride sustained-release tablets and the factors influencing drug release from matrix tablets;
盐酸地尔硫卓缓释片的制备及释药因素考察
2.
Preparation and Studies on Sustained-release and Pulsatile Pellets of Diltiazem Hydrochloride;
盐酸地尔硫卓缓释脉冲微丸的研制
3.
Objective: To observe the inhibitory effect of diltiazem hydrochloride on morphine dependent mice.
目的··:观察盐酸地尔硫卓对小鼠吗啡戒断反应及血清单胺类递质的影响。
2)  Diltiazem HCI(HERBESSER)
盐酸地尔硫卓(合贝爽)
3)  Diltiazem infusion
盐酸地尔硫卓注射液
4)  diltiazem
地尔硫卓
1.
Effect of Diltiazem on the expression of proto-oncogene in proliferated vascular smooth muscle cells;
地尔硫卓对增殖血管平滑肌细胞的原癌基因表达的影响
2.
A Comparative Study on the Efficacy and Safety of Intravenous Diltiazem and Metoprolol in Elderly Heart Failure Patients with Rapid Atrial Fibrillation;
静脉应用地尔硫卓和美托洛尔治疗老年心功能衰竭伴心房颤动快速心室率的疗效和安全性比较
3.
Curative effect and safety of diltiazem in treatment of patients with unstable angina;
口服地尔硫卓治疗不稳定型心绞痛的疗效和安全性
5)  diltiazem hydrochloride sustained-release capsule
盐酸地尔硫芯卓缓释胶囊
1.
Pharmacokinetics of diltiazem hydrochloride sustained-release capsule in healthy volunteers;
两种剂量盐酸地尔硫芯卓缓释胶囊在健康人体药动学及参数相关性
6)  diltiazem hydrochloride
盐酸地尔硫
1.
Determination of diltiazem hydrochloride injection by high-performance liquid chromatography;
高效液相色谱法测定盐酸地尔硫注射液的含量
2.
Study on the industrialization of sustained-release Diltiazem hydrochloride tablets;
盐酸地尔硫缓释片产业化研究
3.
Effect of pH to the stability of diltiazem hydrochloride for injection;
pH对注射用盐酸地尔硫稳定性的影响
补充资料:盐酸地尔硫卓
分子式:C22H26N2O4S·HCl
分子量:450.98
CAS号:33286-22-5

性质:白色结晶或结晶性粉末。熔点187-188℃。易溶于水、甲醇、氯仿,难溶于无水乙醇,不溶于苯。无臭,味苦。

制备方法:由2-氨基硫酚与对甲氧苯基环氧丙酸乙酯缩合得2-(4-甲氧基苯基)-3-羟基-1,5-苯并硫氮杂 -4(5H)-酮。再经酰化、与二甲氨基氯乙烷缩合、成盐制得硫氮卓酮。

用途:钙通道阻滞药,用于室上性心律失常、心绞痛、老年人高血压等。本品为冠脉扩张药,对心绞痛有效。用于运动性绞痛及陈旧性心肌梗塞引起的心绞痛治疗。本品对雌小鼠口服LD50为640毫克/公斤,雄大鼠口服LD50为560毫克/公斤。

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