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1)  Tongxinluo
通心络
1.
Effects of Tongxinluo on Nerve Growth Factor and Brain Derived Neurotrophic Factor after Cerebral Ischemia in Diabetic Rats;
通心络对糖尿病大鼠脑缺血后神经生长因子及脑源性神经营养因子表达的影响
2.
Effects of Tongxinluo on Cerebral Ischemic Tolerance and Expression of Bcl-2 and Bax in Rats with Cerebral Infarction;
通心络对脑梗死大鼠的脑缺血耐受及Bcl-2、Bax蛋白表达的影响
3.
Influence of Tongxinluo on Serum Inflammatory Factors in Patients with Acute Coronary Syndrome;
通心络对急性冠脉综合征患者血清炎性因子的影响
2)  Tongxinluo capsule
通心络
1.
The effect of Tongxinluo capsule on the plasma adhesion molecule in patients with acute coronary syndrome;
通心络对急性冠状动脉综合征患者血浆黏附分子的影响
2.
Clinical observation on the therapeutic effect of Tongxinluo capsule on depression in patients with coronary heart disease;
通心络胶囊治疗冠心病患者抑郁症状的临床观察
3.
Effect of Tongxinluo Capsule on Insulin Resistance in Diabetes Patients with Coronary Heart Disease;
通心络改善糖尿病冠心病患者胰岛素抵抗的观察研究
3)  Tong Xin luo
通心络
1.
The Efficacy and the Mechanism of Tong Xin Luo on the Inhibition of Endothelial Cell Apoptosis Induced by Hypoxia;
通心络抑制缺氧诱导的血管内皮细胞凋亡及机制研究
2.
Objective:To evaluate comprehensively the effect of Tong Xin Luo on the recovery from myocardial infarction.
目的:综合评价通心络促进心梗恢复的效应。
4)  Tong-xin-luo
通心络
1.
The Effect of Tong-xin-luo Capsule on the Cerebrovascular Reserve Capacity in Vascular Dementia Mice;
通心络胶囊对血管性痴呆小鼠脑血管储备能力的影响
2.
The protective effects of Tong-xin-luo on myocardium and microvasculature after reperfusion in acute myocardial infarction;
通心络对急性心肌梗死患者再灌注后心肌和微血管的保护性研究
3.
ObjectiveTo measure serum soluble CD40L(sCD40L)in patients with acute coronary syndromes on Tong-xin-luo therapy, compare with patients on statin therapy, and to evaluate the effect of Tong-xin-luo on stabilization of atherosclerotic plaque and inhibition of immune-inflammation.
目的观察通心络胶囊治疗急性冠脉综合征患者血清可溶性CD40L(sCD40L)的变化,了解其对斑块稳定和免疫炎症抑制的影响。
5)  Tongxinluo Capsule
通心络胶囊
1.
Effect of Tongxinluo Capsule on Platelet Aggregation in Patients with Cerebral Infarction;
通心络胶囊对脑梗死患者血小板聚集功能的影响
2.
Parkinson’s Disease Treated with Tongxinluo Capsule,Liuwei Rehmannia Root Pill and Madopar;
通心络胶囊、六味地黄丸与美多巴合用治疗帕金森病
3.
Clinical understand of Tongxinluo capsule in the treatment of angina pectoris;
通心络胶囊治疗冠心病心绞痛36例观察
6)  Tongxinluo Capsules
通心络胶囊
1.
Clinical study on treatment of coronary slow flow phenomenon with Tongxinluo Capsules;
通心络胶囊治疗冠状动脉慢血流的临床研究
2.
A study on the effciency of Tongxinluo capsules in treating patients with cerebral infarction;
通心络胶囊治疗脑梗塞临床观察
3.
Comparative Study of Tongxinluo Capsules and Sordi in Treatment of Patients with Silent Myocardial Ischemia;
通心络胶囊和硝酸异山梨醇治疗无症状心肌缺血的对照研究
补充资料:通心络
药物名称:通心络

英文名:

药效学研究:
通心络胶囊能明显减轻急性心肌缺血程度,缩小心肌缺血范围,减小心肌梗塞区域。增加冠脉血流量,扩张冠脉血管,能够增强左室作功而不增加心肌耗量,可明显改善垂体后叶素所致大鼠冠脉痉孪性心肌缺血,抑制氯仿引起的小鼠定性心律失常,明显降低含饵性高脂大鼠的血脂水平。
通心络胶囊有增加麻醉犬脑血流量,降低脑血管阻力的作用,对血压、心率无影响;对大鼠血小板聚集有抑制作用,能显著抑制家兔体内血栓形成,能明显延长凝血时间,能够减轻大鼠大脑局部缺血所致的脑组织损伤,缩小梗塞体积,改善神经损伤症状,并降低血液粘度。
毒理学实验:急性毒性实验未见死亡及不良反应;长期毒性实验对大鼠一般状况、体重、血象、心肝肾功能,心电图均无不良影响,各脏器大体及镜下检查亦无中毒性病理改变。
临床研究:通心络胶囊治疗冠心病心绞痛总有效率达96.49%,可逐渐减少或停用硝酸甘油类药物,纠正缺血性心电图,改善率达71.05%,并能抑制室性心率失常,解除胸闷胸痛、心慌气短、乏力出汗等症状。通心络胶囊对于脑血栓及其后遗症总有效率达91.03%,可以缩小脑梗塞面积,恢复脑细胞功能,促进半身不遂、语言不利、口舌歪斜、肢体麻木康复,并能预防冠心病、脑血栓的发生。


类别:防治心绞痛药
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