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1)  Xin Naotongluo Solution
心脑通络液
1.
Objective:To explore the effect of Xin Naotongluo Solution on NO and ICAM-1 of cerebral ischemia in rats,and to set the theory on the use of the drugs on.
目的探讨心脑通络液对局灶性脑缺血急性期大鼠脑组织NO、ICAM-1含量的影响,为治疗脑梗塞的临床用药提供实验依据。
2.
Objective:To explore the effect of Xin Naotongluo Solution on MDA and MMP-9 of acute phase cerebral ischemia in rats through establishing focal cerebral ischemia model in rats,and to set the theory on the use of the drugs on.
目的观察心脑通络液对局灶性脑缺血急性期大鼠脑组织MDA、MMP-9含量的影响,探讨其作用机理,为治疗脑梗塞的临床用药提供实验依据。
2)  Xinnaotongluoye
心脑通络液
1.
Experimental Study on Mechanism of Treating Ischemia Heart Disease with Xinnaotongluoye;
心脑通络液治疗缺血性心脏病机理的实验研究
3)  TLJN Oral Solution
通络救脑口服液
1.
Expression of TNFa and IL-β1 in Aβ1-40 Induced AD in Rats and the Effect of TLJN Oral Solution;
通络救脑口服液对实验性类AD大鼠血清细胞因子含量的影响
2.
Objective:To observe the effect of TLJN Oral Solution on Bax and Bcl-2 mRNA expression in brain tissue of amyloid-β1-40 injection into brain induced experimental AD rats in vivo.
目的:探讨大鼠大脑海马立体定向注射β-淀粉样蛋白1-40对Bax和Bcl-2mRNA表达的影响及通络救脑口服液对其干预作用。
3.
Objective The aim was to observe the therapeutic effect of TLJN Oral Solution about learning and memory abilities on AD Rats induced by amyloidβ1-40 injection in bilateral hippocampus tissue and its mechanism, to provide a scientific ground in clinical applications.
目的观察通络救脑口服液对双侧海马注射Aβ1-40建立的AD模型大鼠学习记忆能力的影响及其干预的分子机制,为该药临床应用提供科学的依据。
4)  tongluojiunao injection
通络救脑注射液
1.
Effects of cortical devascularization on Vimentin,GFAP positive cells located on SVZ of adult rat and the role of Tongluojiunao Injection
通络救脑注射液对成年大鼠侧脑室室管膜下层Vimentin、GFAP阳性细胞的影响
2.
Objective To observe the curative effective and the badness and the side-effective of tongluojiunao injection to the convalescence stage of ischemic apoplexy(cerebral infarction).
目的:观察通络救脑注射液治疗中风病(风火上扰、瘀血阻络证)的临床治疗效果。
3.
Objective To study the influence of conditioned medium of rat brain microvascular endothelial cells on the activity of conical neurons and the protective effect of Tongluojiunao injection.
目的探讨脑微血管内皮细胞条件培养液对神经元活性的影响,以及通络救脑注射液对此过程的干预作用。
5)  TongLuoJmNao Inject
通络教脑注射液
6)  Naoxintong oral liquid
脑心通口服液
1.
Aim To establish a method for determination of puerarin in Naoxintong oral liquid.
目的建立HPLC法测定脑心通口服液中葛根素的含量。
补充资料:通心络
药物名称:通心络

英文名:

药效学研究:
通心络胶囊能明显减轻急性心肌缺血程度,缩小心肌缺血范围,减小心肌梗塞区域。增加冠脉血流量,扩张冠脉血管,能够增强左室作功而不增加心肌耗量,可明显改善垂体后叶素所致大鼠冠脉痉孪性心肌缺血,抑制氯仿引起的小鼠定性心律失常,明显降低含饵性高脂大鼠的血脂水平。
通心络胶囊有增加麻醉犬脑血流量,降低脑血管阻力的作用,对血压、心率无影响;对大鼠血小板聚集有抑制作用,能显著抑制家兔体内血栓形成,能明显延长凝血时间,能够减轻大鼠大脑局部缺血所致的脑组织损伤,缩小梗塞体积,改善神经损伤症状,并降低血液粘度。
毒理学实验:急性毒性实验未见死亡及不良反应;长期毒性实验对大鼠一般状况、体重、血象、心肝肾功能,心电图均无不良影响,各脏器大体及镜下检查亦无中毒性病理改变。
临床研究:通心络胶囊治疗冠心病心绞痛总有效率达96.49%,可逐渐减少或停用硝酸甘油类药物,纠正缺血性心电图,改善率达71.05%,并能抑制室性心率失常,解除胸闷胸痛、心慌气短、乏力出汗等症状。通心络胶囊对于脑血栓及其后遗症总有效率达91.03%,可以缩小脑梗塞面积,恢复脑细胞功能,促进半身不遂、语言不利、口舌歪斜、肢体麻木康复,并能预防冠心病、脑血栓的发生。


类别:防治心绞痛药
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