The reaction of ethylmagnesium bromide with terminal alkynes in THF afforded alkynyl Grignard reagents,which were reacted with alkyl or arylsulfenyl chlorides at 0 ℃ to give the corresponding alkynyl sulfides in high yields.

Preliminary studies on the addition orientation of 2-dialkylthiomethylene-5, 5-dimethyl-1, 3-cyclohexadione with Grignard reagents;

On the basis of the one-carbon unit transfer reaction of tetrahydrofolate coenzymes,six cyclohexyl ketone compounds were synthesized successfully with benzimidazolium salt as the tetrahydrofolate coenzyme model at formic acid oxidation level and Grignard reagent as a nucleophile to which one carbon unit was trans.

Based on the one-carbon unit transfer reaction of tetrahydrofolate coenzymes,n-pentanal was synthesized successfully by using benzoimidazolium salt as the tetrahydrofolate coenzyme model at the formic acid oxidation level and the Grignard reagent as a nucleophile to which one carbon unit was transferred.

Synthesis of benzaldehyde via C_6H_5MgBr;

In this dissertation we studied (Z)-α-silylvinyl Grignard reagents and (E)-α-iodovinylstannanes underwent a cross-coupling reaction in the presence of Pd(PPh_3)_4 catalyst to afford stereoselectively the difunctionalized 1,3-dienes containing silicon ang tin in good yields.