Optimization of cefoselis sulfate synthesis;

5-Amino-1- hydroxyethylpyrazole is the C-3 side-chain of cefoselis sulfate.

Cefoselis sulfate is a new fourth-generation parenteral oximine-type cephalo-sporin in that has potent activity against wide range bacteria including lots of Gram-positive bacteria and Gram-negative bacteria, especially to Staphylococcus aureus and Pseudomonas aeruginosa.

Randomized controlled multicenter clinical trial of cefoselis sulfate for injection in the treatment of acute bacterial infections

Clinical trial of cefoselis on community-acquired pneumonia

Pharmacokinetics of cefoselis injection after a single dose in Chinese healthy volunteers

Determination of Cefotaxime Acid by High Performance Liquid Chromatography;

Determination of the Assay of Residual Solvent in Cefotaxime acid by Headspace Gas - chromatography Methods;

The experimental process on synthesis of cefotaxime acid was studied by using 7 aminocephalosporanic acid (7 ACA) and MEAM as raw material under the catalytic action of DMA.

Research on process of recovery of mother-liquid in synthesis of Cefotaxime;

Cefquinome sulfate was prepared from cefotaxime via 3-substitution,salt formation,and salt exchange with sulfuric acid by anion exchange resin.

Cefotaxime(4) was obtained by reacting 7-ACA(2) with MAEM(3) in THF/H2O with the yield reach 95.