Arginine, glycin and aspastic acid make up of the RGD sequence, which is found in many extracellular matrix.

Based on the structure and function analysis of hirudin,a potent thrombin inhibitor,and some platelet aggregation inhibitors,which contain the recognition sequence Arg Gly Asp(RGD)as their functional motif,two chimeric antithrombotic molecules were designed by introducing RGD sequence to hirudin C terminus.

Influence of RGD peptide on the proliferation and adhesion of human lens epithelial cells in vitro;

By studying the distribution and imaging of ~(131)Ⅰlabelled cyclic RGD(cRGD)peptide in mice bearing melanoma,we will discuss the possibility of ~(131)Ⅰ-cRGD peptide as tumor receptor radiotracer.

Objective To prepare the conjugate of yunnanmycin(YNM) and RGD(Arg-Gly-Asp) peptide for enhancing the cytotoxicity of RGD peptide.

The Cys-RGD peptide is labelled with 99Tcm-nitrido core combined with PNP6 ligand (PNP6=bis(diethoxypropylphosphino ethyl) ethoxy ethylamine) to investigate the possibility of radiolabelled RGD peptides for tumor αvβ3 integrin receptor scintigraphy.

Synthesis of RGD identical-fork-peptide derivative with inhibitive effect on adhesiveness of advanced metastatic tumor cells;

Isolation and identification of rabbit autogenous bone marrow stromal cells and the expression of exogenous transforming growth factorβ1 gene transiently transfected with RGD-containing peptide gene delivery system;