Effect of Endomorphin on Contractile Response of Colon Muscle Strips in Cathartic Colon Rats in Vitro;

Influence of intracerebroventricular administraction of endomorphine-1 on left venteicular systolic pressuer in rats;

Analgesic mechanism of endomorphin in the superficial laminae of the spinal dorsal horn;

Development of Potent Endomorphins Analogs Using Atypical Conformationally Constrained C-Terminus and Characterization of Opioid Activities of Endomorphins and Their Analogs Both in Vivo and in Vitro;

Structure-activity Relationships of the Novel Dimeric, Side Chain and C-terminal Modified Analogs of Endomorphins;

Alterations of the Regulatory Function of Endomorphins on the Cardiovascular System and Bronchoconstriction in Type I Diabetes;

Endomorphins including endomorphin-1(H-Tyr-Pro-Trp-Phe-NH_2, EM1) andendomorphin-2(H-Tyr-Pro-Phe-Phe-NH_2, EM2) were discovered, isolated anddemonstrated to have high selectivity and affinity forμ-opioid receptors in 1997.

The tetrapeptide of endomorphin-2, a strong agonist of the u-acceptor with high affinity and selectivity, was synthesized from L-tyrosine、 L-proline and L-phenylalanine by liquid phase condensation.

Two potent endogenous opioid peptides,endomorphin-1(EM1;H-Tyr-Pro-Trp-Phe-NH_2) and endomorphin-2(EM2;H-Tyr-Pro-Phe-Phe-NH_2),which showed high affinity and selectivity toward theμ-opioid receptor,were isolated from bovine brain in 1997.

Synthesis of endomorphin-1 with mixed anhydride method;

Modification of Endomorphin-1 to Enhance the Blood-brain Barrier Permeability: Design, Synthesis and Biological Activity Characterization;