1) opioid peptide
吗啡样肽
2) endogenous morphine-like peptides
内源性吗啡样多肽
3) endomorphin
内吗啡肽
1.
Effect of Endomorphin on Contractile Response of Colon Muscle Strips in Cathartic Colon Rats in Vitro;
内吗啡肽对“泻剂结肠”大鼠离体肠肌条收缩反应的影响
2.
Influence of intracerebroventricular administraction of endomorphine-1 on left venteicular systolic pressuer in rats;
侧脑室注射内吗啡肽-1对大鼠心功能的影响
3.
Analgesic mechanism of endomorphin in the superficial laminae of the spinal dorsal horn;
内吗啡肽在脊髓背角浅层的镇痛机制
4) Endomorphins
内吗啡肽
1.
Development of Potent Endomorphins Analogs Using Atypical Conformationally Constrained C-Terminus and Characterization of Opioid Activities of Endomorphins and Their Analogs Both in Vivo and in Vitro;
C-末端空间立体构象限制的内吗啡肽的构建以及内吗啡肽及其类似物的生理、药理活性研究
2.
Structure-activity Relationships of the Novel Dimeric, Side Chain and C-terminal Modified Analogs of Endomorphins;
二聚化以及侧链和碳末端修饰的内吗啡肽类似物的构效关系研究
3.
Alterations of the Regulatory Function of Endomorphins on the Cardiovascular System and Bronchoconstriction in Type I Diabetes;
糖尿病病理状态下内吗啡肽对心血管系统及支气管收缩调节功能的变化
5) endomorphin-2
内吗啡肽-2
1.
Endomorphins including endomorphin-1(H-Tyr-Pro-Trp-Phe-NH_2, EM1) andendomorphin-2(H-Tyr-Pro-Phe-Phe-NH_2, EM2) were discovered, isolated anddemonstrated to have high selectivity and affinity forμ-opioid receptors in 1997.
内吗啡肽是一种具有吗啡活性的内源性四肽，包括内吗啡肽-1(H-Tyr-Pro-Trp-Phe-NH_2)和内吗啡肽-2(H-Tyr-Pro-Phe-Phe-NH_2)。
2.
The tetrapeptide of endomorphin-2, a strong agonist of the u-acceptor with high affinity and selectivity, was synthesized from L-tyrosine、 L-proline and L-phenylalanine by liquid phase condensation.
采用先合成两个二肽片段，再合成四肽的合成策略，以酪氨酸(L-Tyr)、脯氨酸(L-Pro)、苯丙氨酸(L-Phe)为起始原料，液相条件下合成出内吗啡肽-2(endomorphin-2，H-Tyr-Pro-Phe-Phe-NH_2)三氟乙酸盐。
3.
Two potent endogenous opioid peptides,endomorphin-1(EM1;H-Tyr-Pro-Trp-Phe-NH_2) and endomorphin-2(EM2;H-Tyr-Pro-Phe-Phe-NH_2),which showed high affinity and selectivity toward theμ-opioid receptor,were isolated from bovine brain in 1997.
1997年,内吗啡肽-1(H-Tyr-ProTrp-Phe-NH_2)和内吗啡肽-2(H-Tyr-Pro-Phe-Phe-NH_2)从牛脑中分离提纯得到,它们是对μ-阿片受体具有高亲和性和选择性的内源性阿片肽。
补充资料：吗啡
| 吗啡 morphine 一种异喹啉型生物碱。分子式C17H19NO3。存在于鸦片中，含量约10％。无色棱柱状晶体。熔点254～256℃，比旋光度  －132°(甲醇)。味苦。在多数溶剂中均难溶解，在碱性水溶液中较易溶解 。它可与多种无机酸 ( 如盐酸、硫酸等 )和多种有机酸 (如酒石酸等) 生成易溶于水的盐 。医药上常使用它的硫酸盐或盐酸盐。吗啡在医药上用作麻醉性镇痛剂，用于解除胆结石、肾结石 、转移性癌等疼痛。在创伤性休克、内出血等情况下用于保护机体避免衰竭 。 对人的致死量为0.2 ～0.3克。吗啡有成瘾性，其二乙酰衍生物 (即海洛因）的成瘾性更大。 |
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参考词条