The influences of the frontier molecular orbitals and optimized geometry of the precursor on the reaction rates and endo/exo selectivity are discussed,and a reasonable explanation about the steroselectivity of 1,3-dipolar cycloaddition reaction in the presence of copper-(Ⅱ)-or.

The effect of the complexes of copper(II) or zinc(II) with 2,2-bis[2,2′-4(S)-benzyl-4,5-dihydrooxazole]propane catalysis on the 1,3-dipolar cycloaddition reactions of diphynyl nitrone with electron-rich ethyl vinyl ether under various reaction conditions is determined.

2%,1-Benzyl-5-phenyl-1,2,3-triazole was prepared through 1,3-dipolar cycloaddition reaction with benzylazide and phenylacetylene,and the yield was 26%.

On the basis of this, 1,3-dipolar cycloaddition reactions were studied using imine esters as the starting marerials.

The triazole compounds(7b and 8b) were obtained by dipolar-cycloaddition reaction from 3b and some carbonyl nucleophilic reagents containing active methylene.

Development of complex in catalytic enantioselective 1,3-dipolar cycloaddition reactions of nitrones;

Novel 4-β-D-allopyranosyloxy-α-chloro-benzaldehydeoxime (3) was synthesized by substitution reaction of 2 with t-BuOCl, and novel 3-(4-β-D-allopyranosyloxyphenyl)-4-aryl-5-aryl-1,2,4-oxadiazoline derivatives (5a～5h) have been synthesized by 1,3-dipolar cycloaddition reaction of 3 with Schiff bases 4a～4h.

Six novel 3-(p-methoxyphenyl)-5-aryl-3a,6a-dihydro-4,6-dioxo-pyrrolino[3′,4′-d]isoxazole derivatives(3a~3f) were synthesized by 1,3-dipolar cycloaddition reaction of N-arylmaleimides and 4-methoxybenzonitrile oxide in the presence of Et3N.