In order to study the molecular pathology of hereditary persistence of fetal hemoglobin (HPFH) in Chinese, PCR based chemical cleavage of mismatch (CCM) method was used for defining the point mutations causing non deletional HPFH.

Clinical study on HbF keep on syndrome

Objective To investigate the role of directly constitutive activation of p38 mitogen-activated protein kinases(p38MAPKs)signaling in γ-globin gene expression and fetal hemoglobin(HbF)induction,and provide direct data for the relationship between phosphorylation of p38 and erythroid differentiation of human K562 erythroleukemia cells.

Objective To investigate the relationship of β-thalassemia mutations and the single nucleotide polymorphism(SNP) at position -158 of G γ-globin gene to the altered levels of fetal hemoglobin(Hb F) of β-thalassemia heterozygotes.

Aim: To investigate the role of sodium butyrate in γ globin gene expression and fetal hemoglobin induction and its mechanisms.

Objective To investigate the association between the -158C/T polymorphism in the promoter of ~G-γhemoglobin gene and high fetal hemoglobin(HbF) in hemoglobin E/β-thalassemia major patients in chinese.

Objective Preparation and characterization of monoclonal antibodies (mAbs) against human fetal hemoglobin(HbF) which can be used as useful tool for detection of HbF.