With many progresses of molecular biological technology in recent years, studies are focusing on the relationship between IGFs and intestinal fibrosis and regulatory factors correlated.

Intestinal fibrosis is a serious complication of many inflammatory bowel diseases and is mainly caused by excessive proliferation of intestinal mesenchymal cells and abnormal deposition of extracellular matrix(ECM).

The fiber momhology observed on SEM ( Scanning Electromicroscope) are evi-dently superior than old plate when beating the thick-wall fiber, Yunnan pine kraft highyield chemical pulp using Φ450 YG02 type new refiner plate, it can be able to affordmore external and internal microfibril and resulting to take a important role of upgrad-ing the quality of sack paper.