Conclusion Leflunomide can inhibit the expression of p-STAT1 and prevents the excess activation of JAK/STAT1 signal transduction pathway,which may be one of the mechanisms for the therapeutic effects in the MRL/lpr lupus mice.

ObjectiveTo investigate the role of interferon inducible protein IFI 16 and JAK-STAT pathway in the pathogenesis of systemic lupus erythematosus(SLE).

Objective To investigate the expression of IFI16 and the function of JAK-STAT pathway in peripheral blood mononuclear cell of patients with systemic lupus erythematosus(SLE).

Here we reported the research advances in type I and II interferon genes and their receptors,the JAK-STAT signal transduction pathway,the interferon regulatory factor family and some interferon-inducible proteins in fish.

Wnt signaling pathway and medulloblastoma;

Three putitive signaling pathways related to cell replicative senescence are p16~ INK4a /Rb,p19~ ARF /p53/p21~ Waf1 and PTEN/p27.

In this study,we use transgenic plants and plant hormone-related mutants in tomato to investigate the cross-talk between systemin/JA and BR(Brassinosteroid)signaling pathways.

Based on the establishment of a high metastasis potential breast cancer cell line LM-MCF-7, derived from MCF-7 cell line, the related factors and their signal transduction pathways were investigated to demonstrate the molecular mechanism of enhanced proliferation and migration of LM-MCf-7 cells.

If the Signal transduction pathways are intervened inside or outside cells,the synthesis of transcription factors and signaling molecules could be blocked.