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1)  INSIG2 gene
胰岛素诱导基因2(INSIG2)
1.
ConclusionThere was no association between INSIG2 gene rs7566605 polymorghism and childhood overweight or obesity in China.
目的研究胰岛素诱导基因2(INSIG2)rs7566605多态性与我国儿童青少年肥胖和代谢异常的相关性。
2)  INSIG2,3T3-L1 cell
胰岛素诱导基因2,3T3-L1细胞
3)  insulin gene
胰岛素基因
1.
GC-box is not a key cis-acting element in human insulin gene promoter;
GC盒不是人胰岛素基因启动子中关键顺式作用元件
2.
Objective: To investigate the effect of glucose on the expression of insulin gene in isolated rat islets, and study the role of non-physiological concentration of glucose in pathogenesis of diabetes mellitus.
目的:研究不同浓度葡萄糖对大鼠胰岛β细胞胰岛素基因表达的影响,探讨非生理浓度葡萄糖在糖尿病发病过程中的作用。
4)  induced pancreatic islet
诱导胰岛
1.
The induced pancreatic islets invevery well which showed positive were suspended in 100 μL DMEM,and transplanted into the subcapsular region of the left kidney of twelve diabetes rats.
DMEM稀释每个阳性孔诱导胰岛细胞至100μL,分别移植在12只糖尿病大鼠左侧肾囊内。
5)  human proinsulin gene
人胰岛素原基因
1.
Construction and identification of the human proinsulin gene recombinant expressing mature insulin in exopancreas;
人胰岛素原基因胰外表达重组体的构建及鉴定
2.
Package of recombinant retroviral vector carrying modified human proinsulin gene and identification of virus titer;
人胰岛素原基因的包装及增殖
3.
Objective To study primarily the safety of transfering recombinant human proinsulin gene plasmid(RHPGP)into diabetic rats induced by streptozotocin.
目的初步研究重组人胰岛素原基因逆转录病毒载体质粒(RHPGP)在糖尿病大鼠体内的安全性。
6)  proinsulin gene
胰岛素原基因
1.
Effect of rat proinsulin gene therapy by intramuscular injection on blood glucose in streptozotocin-induced diabetic rats;
肌肉注射大鼠胰岛素原基因治疗糖尿病大鼠的研究
2.
Aim To study the effect of proinsulin gene therapy on diabetic rats, and construct pseudo- β cell line.
方法 (1)从大鼠胰腺组织中提取总RNA,通过逆转录-聚合酶链反应(RT-PCR)法获得大鼠胰岛素原基因cDNA全长序列,并经EcoR Ⅰ和Hind Ⅲ酶切后,应用基因重组和分子克隆的方法与真核细胞表达质粒pCMV-Script Vector构建重组表达质粒pCMV/proinsulin。
补充资料:胰岛


胰岛
islets of pancreas

  胰腺的内分泌部分,是分散在胰腺中的不规则的细胞群。胰岛至少有三种细胞:A(或α2)细胞分泌胰高血糖素;B(或β)细胞分泌胰岛素;近来又发现一种细胞,称为D(或δ或α1)细胞,它在正常情况下分泌生长激素释放抑制激素。D细胞增生或发生肿瘤时,分泌大量胃泌素,称为胃泌素瘤。可引起胃酸分泌过多的消化性溃疡。胰岛这些细胞紧靠在毛细血管上,所分泌的激素,通过毛细血管壁渗入血液内,有调节糖代谢的作用。
  
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