Two pairs of chiral enantiomers of Anisodamine are baseline separated using HS-γ-CD as the chiral selectors,and one pair of chiral enantiomers of Anisodamine and Atropine are baseline separated using HS-β-CD as chiral selector in the following optimum conditions,5% highly sulfated cyclodextrins in 50 mmol·L-1 triethylammonium phosphate solution(pH 2.

With the method of capillary zone electrophoresis,the paper respectively tests sepration of highly sulfated-β-cyclodextrin(HS-β-CD) on three kinds of chiral amine drugs,under the conditions of phosphate buffer(50 mmol/L,pH2.

The enantiomers of phenyl-1,2-ethanediol, β-methylphenyl-1,2-ethanediol and 1,2-diphenyl-1,2-ethanediol were separated and analyzed with sulfated cyclodextrins (HS-CDs) as chiral selectors in the reversed-polarity capillary zone electrophoresis(CZE) mode.

The effect was increased linearly with increasing the concentration of sulfonated β-cyclodextrin.

Three new kinds of the sodium salt of sulfonated β-cyclodextrins with different degrees of substitution were synthesized and characterized.

Methods:The enantiomers were separated by HPCE on a capillary(50 cm×50 μm,ID) with the running buffer solution of 20 mmol/L of sodium dihydrogen phosphate,which contained 1% sulfated-β-cyclodextrin and was adjusted to pH 3.

High performance capillary electrophoresis separation of chiral drug intermediates with sulfated-β-cyclodextrin as chiral selector;