Rupture of unstable atherosclerotic plaque is an essential pathogenetic mechanism of acute coronary syndrome (ACS), thereby, to stabilize the vulnerable plaque is of great importance for prevention and treatment of ACS.

Objective To investigate the correlation between serum level of relevent cytokines(Matrix metalloproteinase-1,MMP-1,Tissue inhibitor of metalloproteinase-1,TIMP1-1,Intercellular adhesion molecule-1,ICAM-1,vascular intercellular adhesion molecule-1,VCAM-1 and atherosclerotic plaque stability.

Effect of Zhuyu Tongmai capsule on carotid atherosclerotic plaque and blood lipid in patients with transient ischemic attack;

Expression and significance of inflammatory factors and bone formation mediators in carotid atherosclerotic plaque;

Accordingto the results of carotid Doppler ultrasongraphy, patients were re-divide intotwo subgroups: CI with carotid atherosclerotic plaque(34) and CI withoutplaqu.

Methods According to the results of aorta atheromatous plague explored with carotid artery ultrasound at hospitalization,87 patients [49 males,38 females,range 44 to 79 years old and average(59±18)years old] with cerebral infarction were divided into two main groups:Aorta atheromatous plague negative group and aorta atheromatous plague plaque positive grou.