Neurofilament(NF),amyloid-β(Aβ),Bcl-2 and ultrastructure were observed by electron microscope and immunohistochemical staining(SP method).

Mechanisms of Shen-wu capsule inhibiting β-amyloid production in brain of Alzheimer disease model mice;

Effect of Shenwu capsule on inflammatory reaction in rats brain induced by β-amyloid;

Effect of cholesterol depletion on the production of β-amyloid

The effect of TO901317 on the expression of β-secretase and β-amyloid peptide in hippocampal neuron;

Role of mitochondria in neuronal injury caused byβ-amyloid peptide;

The effects of glycosides of cistanche on learning and memory in β-amyloid peptide induced Alzheimers disease in mice and its possible mechanism;

Changes of brain myelin sheath structure and myelin basic protein content induced by amyloid β peptide (Aβ) and effect of GETO on these changes;

Development of an assay for screening β amyloid aggregation inhibitors in vitro and study on inhibitive activity of friedelin;

Objective To establish the cell model of neuroblastoma SK-N-SH cell line impaired by supernatant of THP-1 monocytes which was induced by β amyloid(Aβ1-40),and to investigate the mechanism of neural cell damage.

Methodsβ-amyloid 1-40(Aβ1-40)was injected to the right lateral ventricle of 2-month-old male ICR mice to induce AD model.