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1)  MEK/MAPK pathway
MEK/MAPK通路
1.
AIM:To observe the effect of AngⅡ on retinal pigment epithelial cells(RPE) VEGF secretion and to explore the effect of lethal factor(LF) on VEGF secretion by inhibiting MEK/MAPK pathway.
目的:体外观察血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)对视网膜色素上皮细胞(retinal pigmented epithelium,RPE)VEGF分泌的影响以及能否通过炭疽毒素致死因子(lethalfactor,LF)通过阻断MEK/MAPK通路对VEGF分泌的影响。
2)  Ras/Raf/MEK/MAPK pathway
Ras/Raf/MEK/MAPK通路
3)  Ras/MEK pathway
Ras/MEK通路
4)  MEK/ERK Pathway
MEK/ERK通路
1.
Effect of Kuijieling Decoction on Gene Expression of ITF and MEK/ERK Pathway in Colonic Mucosa of Ulcerative Colitis Rats;
溃结灵对溃疡性结肠炎大鼠结肠粘膜ITF表达及MEK/ERK通路的影响
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5)  MAPK pathway
MAPK通路
1.
Association of tumor metastasis suppressor genes of the MAPK pathway with invasive potential in uveal melanoma;
MAPK通路中肿瘤转移抑制基因对葡萄膜黑色素瘤侵袭能力的影响
2.
Objective:Observe the influence of MAPK pathway s signal transduction in RA synovial cell of experimental rabbits by moxibustion,and reveal the molecular signal mechanism of experimental RA by moxibustion.
结果:造模组与正常对照组相比较,MAPK通路异常激活,Cyclin A1、p38 MAPK、ERK1、JNK1、N-ras等相关信号分子表达上调;艾灸组与造模组相比较,MAPK通路中异常激活的Cyclin A1、p38 MAPK、ERK1、JNK1、N-ras等相关信号分子的表达明显下调。
3.
Besides, IL-22 can stimulate three main MAPK pathways: MEK-ERK, JNK/SAPK and p38 kinase pathway.
此外,IL-22也可激活3条主要的MAPK通路:MEK-ERK、JNK/SAPK和p38激酶途径。
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6)  Ras/MAPK pathway
Ras/MAPK通路
1.
To investigate the biological roles of Ras/MAPK pathway in IL\|6\|induced M1 leukemia cells,the constitutive and inducible activation of Ras/MAPK pathway was blocked with MEK specific inhibitor PD098059 and the effects of PD098059 on IL\|6\|induced growth arrest and terminal differentiation of M1 cells were determined.
为探讨 IL- 6在 M1细胞中激活 Ras/MAPK通路的意义 ,以 MEK激酶的特异性抑制剂PD0 980 59阻断 Ras/MAPK通路的组成型激活及诱导激活 ,观测 PD0 980 59对 IL - 6诱导的 M1细胞生长停止及终末分化的影响 。
补充资料：MEK
     结构式为CH3CH2OCH3，分子量72．1。无色透明液体，有似丙酮气味。相对密度(20 ℃／4℃)0.8049，凝固点-86．9℃，沸点79．6℃，闪点(开口)-5．6℃，燃点515.6℃，粘度(25℃)0．42mPa·s，20℃时水中溶解度26．8％(wt)，溶解度参数δ＝9．3。溶于水、乙醇和乙醚，可与油混溶。易燃，蒸气与空气形成爆炸性混合物，爆炸极限1．81％-11. 5％(vol)。低毒，LD503980mg／kg，空气中最高容许浓度590mg／m3。
    甲乙酮能溶解某些树脂和橡胶，是氯丁橡胶和聚氨酯橡胶的优良溶剂。
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