Construction of the retrovirus vectors carrying the IL-17 or siRNA-IL-17 genes and expression of IL-17 gene in the transgenic diabetogenic T cells

Influence of glucosidorum tripterygii tororum on expression of interleukin-23,interleukin-17 and interleukin-12 in colonic tissues of mice with colitis;

Interleukin-17(IL-17),a cytokine produced by the Th17-cell subset,may promote the recruitment and activation of neutrophils in the airway by inducing the release of the chemokine CXCL8(IL-8) and is prominent in airway wall remodeling of chronic airway inflammatory disease.

Objective To observe the change of interleukin-17(IL-17)in peripheral blood and endothelial function by endothelin-1(ET-1)、nitric oxide(NO)of pulmonary hypertension(PH)associated with congenital heart disease(CHD),and collect the correlation factors of clinical datas,to discuss the role IL-17 in the development of CHD with PH.

AIM:To develop a gene therapy vector of interleukin-1 receptor II(IL-1RII) with recombinant adenovirus and express IL-1RII in the eutopic stromal cells of endometriosis(EM).

Study of single nucleotide polymorphisms in IL-17B gene in Chinese Han people in Shanghai;

IL-12,IL-18 gene modulates immune responses induced by HIV-1 envelope nucleic acid vaccine;

Objective To investigate the anti-tumor efficacy of combinative application of VP3 and IL-18 in human osteosarcoma cell line S-180.

Anti-tumor effects of hIL-2 gene-modified human hepatocytes after intraperitoneal transplantation;

Effects of thymulin on proliferation and differentiation of chicken splenic lymphocytes cultured in vitro and on IL-2 gene expression and secretion of IL-2;

Based on the published nucleotide sequence of canine(Canis familiaris)IL-2 gene, a pair of RT-PCR primers were designed and synthesized.