α-Carbonyl-N,N-acetals were prepared via the reaction of α-cinnamoyl-dibenzyl-thioacetals with ethylenediamine using triethylamine as the catalyst,Further,intramolecular Aza-Michael addition reactions occurred,and three new tetrahydroimidazo[1,2-a]pyridone compounds in moderate yields were synthesized.

In this thesis, the studies are carried on the imidazo[1,2-a]pyridine-based structures, including design and synthesis of imidazo[1,2-a]pyridine derivatives for certain biologically actives, synthetic methodology for novel imidazo[1,2-a]pyridine derivatives.