1) hepatocyte-specificβ-catenin deletion
肝细胞特异性β-catenin基因敲除
3) somatic gene targeting
体细胞基因敲除
4) β-catenin gene
β-catenin基因
1.
Abnormalities of APC gene/β-catenin gene in Wnt pathway in desmoid-type fibromatosis;
韧带样型纤维瘤病Wnt通路中APC/β-catenin基因异常
2.
Objective To explore the relationship of the expression of β-catenin gene with pathological type of craniopharyngiomas and prognosis of the patients with craniopharyngiomas.
目的探讨β-catenin基因和颅咽管瘤病理类型及预后的关系。
3.
PurposeTo analyze the clinicopathologic features of desmoid-type fibromatosis, and to detect trisomy 8 and mutations of the APC gene and β-catenin gene in this tumor with a purpose of exploring the mechanism of the tumorigenesis and progression of this disease.
运用免疫组织化学EnVision~+两步法检测69例存档石蜡包埋组织中β-catenin、cyclinD1、c-myc、Ki-67等蛋白的表达;用DNA末端转移酶介导的缺口标记法(Terminal Deoxynucleotidyl Transferase biotin-dUTP Nick End Labeling,TUNEL)检测病变中细胞凋亡;用聚合酶链反应(PCR)-变性液相高效质谱分析(Denaturing High Performance Liquid Chromatography,DHPLC)-直接测序的方法检测APC和β-catenin基因突变。
5) hepatocyte growth factor β gene
肝细胞生长因子β基因
补充资料:周期性特异性药物
周期性特异性药物
仅能杀灭*细胞增殖周期中某一期癌细胞的抗癌药物。依其作用又分为两类:①作用于S期药物,如*羟基脲、*阿糖胞苷,甲氨蝶呤、巯基嘌呤、硫鸟嘌呤等。其中前两种药物特异性较高,主要干扰DNA合成,但因也能干扰 RNA的合成,可能起到一定的自限作用。临床上宜缓慢静滴或肌注给药。②作用于M期的药物,如长春新碱等。
说明:补充资料仅用于学习参考,请勿用于其它任何用途。
参考词条