The Role of Cav-1 on the Transformation, Apoptosis and N-glycans Branch Formation of Mouse Hepatoma Cells

Objective: The aim in this study was to synthesize a novel chitosan derivative, galactosylated chitosan (GC), and prepare norcantharidin-associated galactosylated chitosan nanoparticles (NCTD-GC-NPs) with GC as hepatocyte-targeting carriers and norcantharidin (NCTD) as model drug against primary liver carcinoma.

METHODS Norcantharidin-associated galactosylated chitosan nanoparticles were achieved by ionic cross-linkage process with galactosylated chitosan as carrier.

Synthesis of N-succinyl-chitosan and the physical-chemical properties;

Study on Synthesis and properties of N-succinyl-chitosan;

Effects of various factors on the intrinsic viscosity of N-succinyl-chitosan;

N-alkyl-lactosylated-O,N-carboxymethyl chitosan are prepared by carboxymethyl-chitosan with alkyldehyde and lactose.

Objective To prepare microbubble,made of N-carboxymethyl chitosan, as ultrasound contrast agent and evaluate its characteristics and acoustic effects in vivo.

Study on the transdermal permeation enhancing effect of N-trimethyl chitosan on the halcinonide ointment in vitro;

Study on the penetration effect of N-trimethyl chitosan on Cyclosporin;

OBJECTIVE To study the effect of degree of quaternization and concentration of N-trimethyl chitosan on the rectal absorption of insulin liquid suppositories.