1) PEG-chitosan nanoparticles
PEG化壳聚糖纳米粒
2) Lectin anchored chitosan nanoparticles
凝集素化壳聚糖纳米粒
3) chitosan nanoparticles
壳聚糖纳米粒
1.
Preparation and characterization of adriamycin-loaded chitosan nanoparticles surface-modified with glycyrrhizin;
甘草酸表面修饰阿霉素壳聚糖纳米粒的制备及特性研究
2.
METHODS Ovalbumin(OVA),used as a model antigen,was entrapped within chitosan nanoparticles by an ionotropic gelation technique.
目的研究壳聚糖纳米粒作为蛋白类疫苗的新载体,并评价其鼻腔给药后所产生的免疫效果。
3.
OBJECTIVE To investigate the effects of CpG ODN prepared by chitosan nanoparticles on immune response in BALB/c mice with hepatitis B vaccine.
目的:探讨应用包裹在壳聚糖纳米粒中的胞嘧啶-鸟嘌呤的脱氧寡核苷酸(CpG ODN)增强小鼠对乙肝疫苗的免疫应答。
4) chitosan nanoparticle
壳聚糖纳米颗粒
1.
Then the recombinant VR1C was entrapped with chitosan nanoparticles(CNP) prepared by the method of ionic cross linkage,and employed to inject muscularly 3-weeks old Kunming mice.
为研制安全高效免疫调节剂增强动物免疫抗病能力,本实验设计合成含11个CpG基序的寡聚核苷酸,重组构建含CpG的VR1012质粒(VR1C);制备壳聚糖纳米颗粒包裹重组质粒(CNP-VR1C),肌注接种3周龄昆明小鼠;接种后28天口服大肠杆菌攻毒观察小鼠天然免疫的变化和对强毒感染的抵抗力,Sandwich ELISA测定血清免疫球蛋白和白细胞介素含量。
2.
The recombinant eukaryotic expression plasmid with the porcine IL-2 gene and CpG motifs were entrapped with chitosan nanoparticles(CNP) prepared by the method of ionic cross linkage,designa-ted as CNP-VRIL2S-VR1C,and then were injected intramuscularly into pigs at 0.
将改组的猪白细胞介素-2基因(VRIL2S)与重组CpG(VR1C)质粒经离子交联法制备的壳聚糖纳米颗粒(CNP)包裹后(CNP-VRIL2S-VR1C),肌肉注射给已接种猪伪狂犬病灭活疫苗的免疫猪,接种后第7、14、28、42和56d采集静脉血检测猪的免疫应答变化,并测定血清免疫球蛋白和白细胞介素含量。
3.
Then the recombinant VR1C was entrapped with Chitosan nanoparticles (CNP) prepared by the method of ionic cross linkage, and employed to inject muscularly 3-weeks old Kunming mice; the blank VR1012 packed with CNP and saline were used to inoculate mice a.
为研制安全高效免疫调节剂增强动物免疫抗病能力，本实验设计合成含11个C pG基序的寡聚核苷酸，重组构建含CpG的VR1012质粒(VR1C)；制备壳聚糖纳米颗粒包裹重组质粒(CNP-VR1C)，肌注接种3周龄昆明小白鼠，设壳聚糖包裹空质粒和生理盐水对照组；接种后28天口服大肠杆菌攻毒观察小鼠天然免疫的变化和对强毒感染的抵抗力，Sandwich ELISA测定血清免疫球蛋白和白细胞介素含量。
5) Chitosan nanoparticles
壳聚糖纳米颗粒
1.
In order to develop a safe and effective immunoadjuvant to enhance the immunity of human to resist HBV infection,an novel CpG Oligodeoxynucleotides(CpG ODN) containing 11 CpG motifs was synthesized and entrapped with chitosan nanoparticles(CNP) which prepared by ionic cross linkage method,and employed to intramuscular injection on 6 weeks old Kunming mice with 5 μg HBsAg vaccine/ capita.
为探索高效安全的分子免疫增强剂,本实验设计合成含11个CpG基序的寡聚核苷酸(CpG ODN),制备壳聚糖纳米颗粒包裹CpG ODN,研究新型CpG ODN壳聚糖纳米颗粒(CpG-CNP)对人乙型肝炎疫苗的免疫佐剂效应。
6) chitosan nanoparticle
壳聚糖纳米粒
1.
OBJECTIVE To select norcantharidin as module drug and synchronously optimize the preparation of low molecular weight(LMW)chitosan nanoparticles(CS-NP)through orthogonal design combined with multi-variable regression analysis.
目的以去甲基斑蝥素为模型药物,运用正交设计及多元回归分析多指标综合优化其低相对分子质量壳聚糖纳米粒制备工艺。
2.
Objective: To prepare appropriate chitosan nanoparticles by optimizing theexperimental condition.
目的： 优化实验条件，制备合适的壳聚糖纳米粒，并连接上pEGFP-C_1质粒，研究壳聚糖纳米粒对DNA的结合和保护能力，利用培养的HepG-2细胞进行转染，评估其转染性，比较壳聚糖纳米粒与阳离子脂质体的转染率。
3.
Methods Chitosan nanoparticles integrating plasmid DNA encoding green fluorescent protein (GFP) and three different types of chitosan [quaternized chitosan (TMO-60%), C(43-45KDa, 87%), and C(230KDa, 90%)] were made by complex coacervation process.
目的考察壳聚糖纳米粒载体的体内外基因转染活性,寻找出最佳转染条件。
补充资料：PEG
聚乙二醇又称聚乙二醇醚，简称PEG，结构式为HO(CH2CH2O)nH，根据分子量大小不同，可从无色透明粘稠液体(分子量200～700)到白色脂状半固体(分子量1000～2000)直至坚硬的蜡状固体(分子量3000～20000)，相对密度(20℃／20 ℃)1．12～1.15。作为增韧利用的聚乙二醇主要是分子量200～600的室温下为无色透明的粘性液体，无味。易溶于水，溶于甲醇、乙醇、丙酮、醋酸乙酯、苯、甲苯、二氯乙烷、三氯乙烯等．不溶于脂肪烃。对酚类溶解能力强，当皮肤上附有苯酚、甲酚时，可用分子量约400的聚乙二醇除去。与硝酸纤维素、松香、酪阮可以混合．但对一般的合成树脂不溶解，对橡胶也不溶胀。吸湿性大。聚乙二醇在正常条件下是很稳定的，但在120 ℃或更高温度下能与空气中的氧发生氧化作用。加热至300 C产生断裂或热裂解。聚乙二醇不挥发．闪点高，对金屑无腐蚀性。无毒，对眼睛和皮肤无明显刺激，LD5033000～43000mg/kg。
用作环氧树脂和聚乙烯醇的增韧剂。
贮存于干燥的库房内，远离火源。
用作环氧树脂和聚乙烯醇的增韧剂。
贮存于干燥的库房内，远离火源。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条