The algorithm simulated the natural process of the meta-population mechanism,such as initial the populations,the fitness of the population and the individual,selecting,cloning and mutating,crossover procreating,cloning of the mnemonic B cells,the depopulation of the sub-population,and the migration of risk of .

The abnormality of FcγRⅡB_1-mediated signaling and the hyperactivity of B cells from patients with systemic lupus erythematosus;

Relationship between CD5~+ B cells and dilated cardiomyopathy;

Detection and of CD5-positive B cells in peripheral blood mononuclear cells of patients with chronic HCV infection and its clinical significance;