To establish a method to evaluate the effects of chemosensitizer on P-glycoprotein using 99mTc-MIBI, and observe the changes of 99mTc-MIBI uptake kinetics and P-glycoprotein levels after using verapamil in MDR human breast cells MCF-7/Adr.

Photometric Determination of Ascorbic Acid With Cetyltrimethyl Ammonium bromide as Sensitizer;

Based on the relationship between molecular structure of a chemical and ability of absorbing microwave energy, targeting microwave hyperthermia sensitizers, aimed to be used in the treatment of tumor, were designed and synthesized in this study.

Mechanisms of action of novel cardiotonic agents——calcium sensitizers;

Levosimendan is a new kind of calcium sensitizers with enhancing myocardial contractility and activating ATP-sensitive potassium channels,but without increasing intracellular calcium load;and thus providing anti-heart failure,anti-myocardial stunning,and decrease of peripheral vascular resistance,and together with relaxation of coronary artery and pulmonary vessels.

Now, there have been several classes of agents available for treatment of-congestive heart failure,such as endothelium receptor inhibitors,β-blockers,calcium sensitizers,diuretics,aldosterone receptor antagonists.

Effects of a new calcium sensitizer MCI-154 on vasoreactivity of hemorrhagic shock rats;

The antishock effects and its mechanism of a calcium sensitizer--MCI-154;

AIM To explore if there is a differential effect of MCI-154 〔 6-[4-(4′-pyridylamino) phenyl]-4,5-dihydro-3(2H)-pyridazin one hydrochl oride trihydrate〕, a calcium sensitizer, on hypertrophied hearts compared with normal hearts and the possible mechanisms underlying it.