Synergistic effect of CYP3A and P-glytoprotein on the first-pass effect of drugs in the intestine;

Since Pang set up the perfused rat intestine-liver preparation,and apply it to study the disposition of enalapril,this model is widely considered to has the particularly advantage in study the absorption,metabolism and first-pass effect.

The theory of the first direct piezoelectric effect and the secondary converse piezoelectric effect is analyzed and confirmed by experiments.

This paper mainly introduces that the Stark fission energy of the hydrogen atoms in the outer-field is calculated by the perturbation method,and discusses the secondary effect and the question on the ionization of the hydrogen atoms in the strong outer-field.

Standard formation enthalpies of substituted benzene and benzoic acids derivates are related to the primary effect, secondary effect and the barrier point of the substituent.

The standard enthalpies of formation of substituted benzene are related to the primary effect, secondary effect and the barrier point of the substituing groups.