Current research indicated that CSFV could evade the immune response and establish persistent infection through regulating cytolysis, inducing dendritic cell unresponse, inducing lymphocyte apoptosis, inhibiting the production of interferon type I and.

Objective Establishing the model of human cytomegalovirus primary infection in BALB/c mice, We aimed to know the stage which cognitive impairment was showed by investigating the effect of HCMV persistent infection on the learning and memory capability in mice and the pathological change in brains of mice.

On the contrary,some picornaviral proteins inhibit apoptosis,enable infection-cells not to die,and to form persistent infection.

Management of delayed infection after internal fixation of thoracic-lumbar spine with pedicle screw via posterior approach;

Primary infection of nervous system often presents in later period of AIDS and its clinical presentations is complicated,which is similar with clinical presentations of opportunistic infection of nervous system,with high mortality rate and the curative effect is poor.