1) inositol phosphatidyl transferase
肌醇磷脂酰转移酶
2) phosphatidylinositol transfer protein alpha
磷脂酰肌醇转移蛋白α
1.
Cloning and prokaryotic expression of phosphatidylinositol transfer protein alpha gene in Taenia saginata asiatica and the immunologic analysis of the recombinant protein;
亚洲牛带绦虫磷脂酰肌醇转移蛋白α基因的克隆表达和免疫学分析
3) Phosphatidylinositol phospholipase C
磷脂酰肌醇磷脂酶C
4) Lecithin-cholesterolacyltransferase
卵磷脂胆固醇脂酰转移酶
1.
Twenty four hours after the operation, the spinal lesion and neighbor areas were moved for examination of lecithin-cholesterolacyltransferase mRNA expression by Retrograde Polymerase Chain Reaction technique (RT-.
卵磷脂胆固醇脂酰转移酶可促进组织、细胞内胆固醇的清除、维持细胞胆固醇稳态,在磷脂代谢中有重要的作用。
5) phosphatidylinositol 3-kinase
磷脂酰肌醇3-激酶
1.
Background &Objective:Phosphatidylinositol 3-kinase(PI3-K)has been implicated in the signaling pathways regulating cell growth by v irtue of its activation in response t o various mitogenic stimuli,but the role of PI3-K in human tumorigenesis has not yet to be defined.
背景与目的:磷脂酰肌醇3-激酶(phosphatidylinositol3-kinase,PI3-K)可被多种有丝分裂信号刺激活化,它参与有关细胞生长信号的调控,但其在人类肿瘤中的作用尚不清楚。
2.
Objective: To investigate the role of phosphatidylinositol 3-kinase ( PI3K ) pathway in angiotensin II ( Ang II ) - and insulin-induced protein synthesis, and to study the mediation of this pathway in the phosphorylat ion of 4E-binding protein 1 ( 4E-BP1 ) and p70 S6 kinase in vascular smooth muscle cells.
目的：研究磷脂酰肌醇3-激酶(P13K)信号通路对血管紧张素Ⅱ(Ang Ⅱ)与胰岛素(Insulin)诱导的血管平滑肌细胞蛋白质合成的影响，及该信号系统对4E结合蛋白1(4E-BP1)和核糖体蛋白S6激酶磷酸化的介导作用。
3.
Objective:To investigate the roles of phosphatidylinositol 3-kinase(PI3K) in the regulation of expression of vascular endothelial growth factor(VEGF) in hepatocellular carcinoma(HCC) cells.
目的:研究磷脂酰肌醇3-激酶(PI3K)信号通路在肝癌细胞血管内皮生长因子(VEGF)表达调控中的作用。
6) phosphatidylinositol 3-kinase
磷脂酰肌醇3激酶
1.
Activation of phosphatidylinositol 3-kinase/protein kinase B induced by trypsin in neutrophils;
磷脂酰肌醇3激酶/蛋白激酶B信号转导通路在胰蛋白酶激活中性粒细胞中的作用
2.
Objective To explore if the effect of connective tissue growth factor on the transdifferentation of human hypertrophic scar fibroblasts is mediated by phosphatidylinositol 3-kinase/ protein kinase B(PI3K/PKB) signal pathway.
目的:探讨磷脂酰肌醇3激酶/蛋白激酶B信号通路是否介导结缔组织生长因子促人增生性瘢痕成纤维细胞转分化。
3.
Objective:To study the effect of chronic alcohol intake on expression of PI-3K-p85α (p85 regulatory subunit of phosphatidylinositol 3-kinase) in skeletal muscle of rats and explore the molecular mechanism of alcohol induced insulin resistance.
目的:研究酒精长期作用下对大鼠骨骼肌磷脂酰肌醇3激酶(phosphatidylinositol 3-kinase,PI-3K)调节亚基p85αmRNA及蛋白水平表达的影响,探讨酒精引起胰岛素抵抗的相关分子机制。
补充资料：卵磷脂胆固醇脂酰转移酶
卵磷脂胆固醇脂酰转移酶（lecithin-cholesterolacyltransferase，lcat）由肝合成释放入血液，以游离或与脂蛋白结合的形式存在，是一种在血浆中起催化作用的酶，其作用是将hdl的卵磷脂的c2位不饱和脂肪酸转移给游离胆固醇，生成溶血卵磷脂和胆固醇酯。血浆胆固醇几乎70％-80％是胆固醇酯，均是lcat催化生成所致。lcat常与hdl结合在一起，在hdl颗粒表面活性很高并起催化作用，对vldl和ldl的颗粒几乎不起作用。lcat在磷脂代谢中有重要的作用。
lcat由416个氨基酸残基组成，分子量为6.3ku。属于糖蛋白，糖链约占24％，是维持其活性必不可少的组分，富含glu、asp、gly、pro、leu。每一酶分子含4个cys，其中两个连成二硫键。根据与胰脂酶序列的同源性比较，推测六肽ⅰ178-g-h-s-l-g183可能是酶的活性中心ｃ傅鞍椎摩谅菪ⅵ?折叠和其他结构比例分别为21％、24％和55％。lcatmrna约为1400bp组成，其信号肽是440个氨基酸组成的密码子。
lcat选择性底物是hdl，特别是新生盘状或小球形hdl3。hdl核心是lcat酶反应产物胆固醇酯的贮存库，并通过胆固醇酯转移蛋白将ce转移至其他脂蛋白和细胞膜，并与其交换。
lcat除肝细胞合成外，在小肠、脾、胰、胎盘、肾上腺等组织细胞发现有lcat的mrna，推测也可合成lcat。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条