3-bromothiophene was synthesized from thiophene through bromination to give 2,3,5-tribromothiophene,then reduced by Zinc in acetic acid.

3-Iodothiophene was synthesized from 3-bromothiophene and KI by coordination catalytic iodination using CuI/different 1,2-diamine ligands as catalysts.

2-(3-Thieny1) malonic acid was synthesized from 3-bromothiophene with coordinative catalyst,through a new route,namely iodination,condensation,hydrolysis and acidification.

Synthesis research of intermediate 2-bromothiophene;

C—Br Bond Dissociation Mechanisms of 2-Bromothiophene and 3-Bromothiophene at 267 nm;