Study on the determination of Ticarcillin disodium and testing of related substances by HPLC;

As an important side chain intermediate, 3-thiophenemalonic acid (3-TMA) can react with 6APA to produce Ticarcillin which can be prepared from Benzylpenicillin and penicillin analysis by degradation under alkaline conditions.

3-thienylmalonic acid has pharmaceutical importance as the side-chain intermediate used in the production of the semisynthetic β-lactam antibiotic ticarcillin(A).

Investigation of the stability of the Ticacillin sodium and Clavulanate potassium for injection by classic isothermal kinetic method and initial uniform velocity method;