Pharmacological and Clinical Development of a Novel Hyupoglycemic Agent:Benfluorex;

Background:Benfluorex,as an amphetamine-type drug,since came out in 1976,had been widespread in clinical application,after the late 80\'s to early 90\'s,at a large number of basic and clinical research to confirm its hypoglycemic effect,indications have been extended to glucose and lipid metabolism disorders,diabetes,obesity and so on.

It is the first clinical trial for benfluorex on Chinese type 2 diabetes, with metformine as positive control.

Study on the Resistance of Klebsiella Pneumoniae Induced by Ciprofloxacin and Sparfloxacin in Vitro;

Effects of sparfloxacin on chromosome aberration of CHL cell in vitro;

Determination of sparfloxacin in plasma and its pharmacokinetics;