The recombinant Sorangium cellulosum in which the epoK gene has been inactivated by random mutagenesis and so produces only epothilone D and C,does not produce epothilone A or B,duo to an alteration in the genes coding for the epothilone polyketide synthase(PKS).

The main total syntheses of naturally occurring epothilones and their derivatives are reviewed.

This paper focuses on the production of epothilone,a kind of secondary anti-cancer metabolite fermented by Sorangium cellulosum DSM11999.

The main structure and biological activity of naturally occurring epothilones and their derivatives were reviewed.

Novel macrolides epothilones, produced by cellulolytic myxobacterium Sorangium cellulosum , have the activity to promote microtubule assembly, and are considered to be a potential successor to the famous antitumor drug taxol.

The way epothilones inhibite the microtubule depolymerization is similar to Taxol.

Although structural distinct, the mechanism of epothilones is similar to the anticancer drug paclitaxel (Taxol), involving induction of tubulin polymerization and stabilization of microtubule assembly.

Preparation and Characterization of Monoclonal Antibodies to Nucleoprotein of Ebola Virus and Marburg Virus;

The most effective way to prevent and cure Ebola virus is vaccine.

Ebola virus GP and VP30 are essential activators of viral transcription.

Quantitative analysis of microbic metabolin EpoB by high performance liquid chromatography;