Hepatopoietin Is an Autocrine Stimulator for Autonomous Growth in Hepatoma Cell Line;

Hepatopoietin (HPO) is a novel human hepatotrophic growth factor, an orthologue of rat ALR (augmenter of liver regeneration) or HSS (hepatic stimulator substance), which specifically stimulates proliferation of cultured primary hepatocytes in vitro and liver regeneration after liver partial hepatectomy in vivo.

Objective:To make antibody against hepatopoietin(HPO)based on B cell epitopes.

The effect of prohepatocyte growth factor(PHGF)and atuomulan on hepatic cirrhosis with disfunction;

Affects of the 3′ untranslated region on expression of recombinant human hepatopoietin;

Studies on chemicophysical properties of recombinant human hepatopoietin;

This article mainly introduces the progress in the study on human hepatopoietin including its discovery, purification of protein, molecular cloning, development of genetic engineering and its functional identification, and discusses its possible roles in liver regeneration and its potential therapeutical application in the treatment of fulminant hepetic failure.